藉由芳香環轉換來合成4,5,6,7-四氫異??; Forming 4,5,6,7-tetrahydroisoindoles through aromaticity

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/6165

Title:	藉由芳香環轉換來合成4,5,6,7-四氫異??;Forming 4,5,6,7-tetrahydroisoindoles through aromaticity
Authors:	謝易達;Yih-Dar Hsieh
Contributors:	化學研究所
Keywords:	4，5，6，7-四氫異吲哚;4，5，6， 7-tetrahydroisoindoles
Date:	2005-06-24
Issue Date:	2009-09-22 10:14:32 (UTC+8)
Publisher:	國立中央大學圖書館
Abstract:	中文摘要氮取代之異吲哚啉可在鈀金屬催化下還原氫化為四氫異吲哚，並且有不錯的產率。藉由氫之同位素標定來探究其反應機制，同時也發現有氫/氘交換的反應產生，並且驗證芳香性在此反應中是必要的。吲哚啉也可在鈀金屬催化下轉換為吲哚。 Abstract The high-yield syntheses of 4,5,6,7-tetrahydro-isoindoles from N-substituted isoindolines under palladium catalyzed hydrogenation conditions are reported. Mechanistic study with deuterated and saturated substrates shows extensive H/D exchange and the essence of aromaticity in this transformation. Indolines can also transform to indoles under palladium catalyzed hydrogenation conditions.
Appears in Collections:	[Graduate Institute of Chemistry] Electronic Thesis & Dissertation

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