血清素受體2B在疼痛之角色;The Roles of Serotonin Receptor 2b in Pain

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题名:	血清素受體2B在疼痛之角色;The Roles of Serotonin Receptor 2b in Pain
作者:	孫維欣
贡献者:	國立中央大學生物科技與生醫工程中心
关键词:	基礎醫學;藥學
日期:	2012-12-01
上传时间:	2014-03-17 11:49:29 (UTC+8)
出版者:	行政院國家科學委員會
摘要:	研究期間：10108~10207;Non-steroid anti-inflammatory drugs are well-known drugs against inflammatory pain, but also have side effects. Understanding of the molecular mechanism of inflammatory pain is important to identify specific targets for clinical treatment. Inflammation resulting from tissue injury, infection or tumor growth often produces chemical mediators (such as 5-HT, prostaglandin E2, bradykinin), inducing chronic and persistent pain. Serotonin released from mast cells or platelets in the peripheral tissues is one of important inflammatory mediators in causing pain and hyperalgesia. The presence of multiple 5-HT receptors on primary afferent nociceptors reflects 5-HT-induced pain or hyperalgesia through different receptors with distinct mechanisms. Despite the potential importance of 5-HT in hyperalgesia, the involvement of 5-HT receptor subtypes in hyperalgesia and cellular mechanisms remain to be clarified. Our preliminary experiments have found that antagonist of 5-HT2B/2C inhibits 5-HT-induced mechanical hyperalgesia. Given that 5-HT2C is not present in DRG neurons and antagonist inhibition is a short-time effect, suggesting that 5-HT2B is involved in 5-HT-induced mechanical hyperalgesia. However, whether 5-HT2B participates 5-HT-induced pain and what is molecular mechanism of 5-HT2B-mediated hyperalgesia remain unclear. The objective of this application is to elucidate the role of serotonin receptor, 5-HT2B in pain. The central hypothesis of this application is that 5-HT2B mediates 5-HT signaling to regulate ion channels related to mechanical hyperalgesia. The proposed work is innovative, as it is the first study to determine the role of 5-HT2B in pain. It is expected to yield the following outcomes: elucidation of molecular mechanism of 5-HT2B–mediated mechanical hyperalgesia and elucidation of involvement of 5-HT2B in inflammatory pain. These results will be important because they are expected to facilitate understanding of molecular mechanisms of inflammatory pain and to fundamentally advance the fields of pain research and development of new anti-inflammatory drugs.
關聯:	財團法人國家實驗研究院科技政策研究與資訊中心
显示于类别:	[生物科技與生醫工程中心] 研究計畫

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