功能性擴散光學斷層造影系統分析設計製作暨驗證;Design, Implementation and Justification of Functional Diffuse Optical Tomographic System

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Title:	功能性擴散光學斷層造影系統分析設計製作暨驗證;Design, Implementation and Justification of Functional Diffuse Optical Tomographic System
Authors:	潘敏俊;孫盛義
Contributors:	國立中央大學生物醫學工程研究所
Keywords:	醫學工程
Date:	2012-12-01
Issue Date:	2014-03-17 11:50:00 (UTC+8)
Publisher:	行政院國家科學委員會
Abstract:	研究期間：10108~10207;Near-infrared (NIR) diffuse optical tomography (DOT) is a method for imaging biological tissue that has currently been developed since 1990s. For its sensing mechanism, it has been widely accepted that NIR tomography offers a way to noninvasively quantify and monitor changes in tissue hemoglobin concentration and oxygen saturation simultaneously, as well as several other chromophores, such as water, lipids, and cytochrome-c-oxidase. The ability to noninvasively quantify these chromophores is important for understanding physiological function and pathophysiological changes within tissues. For this three-year research project, thanks to related leading studies, including (1) two NIR DOT scanning devices using single rotating-source/detector mechanism have been designed and implemented. Compared with existing systems developed by other research groups, this scanning instrument can dramatically save source- and detection-fiber-bundles, and expect to offer comparable functionality. Additionally, the system achieves high angular spatial-resolution superior to other systems; although it needs longer NIR acquisition time. (2) A mammogram-based DOT module was implemented on a commercial mammographic system. Clinic trials for academic investigation justified its effectiveness. Based upon current promising results, in the proposed study for the next three years the following tasks are planed.  Multi-wavelength functional DOT computation scheme－ to distinguish various tissue components in the tomographic images.  Tissue optical-coefficient database using a double-sphere system－ to obtain true absorption- and scattering-coefficient images.  Investigation on spatial resolution of DOT－ to evaluate the spatial resolution of DOT through experimentation.  Design and implementation of prostrate-type diffuse optical tomographic system－ to build up a test bench for clinical trials.  Justification of DOT through clinical trials－ to evaluate the sensitivity, specificity of DOT in breast tumor detection.
Relation:	財團法人國家實驗研究院科技政策研究與資訊中心
Appears in Collections:	[Institute of Biomedical Engineering] Research Project

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