English  |  正體中文  |  简体中文  |  Items with full text/Total items : 66984/66984 (100%)
Visitors : 22947863      Online Users : 400
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/63015


    Title: 基於基因表現資料辦識轉錄調控模組之系統;A system to identify transcriptional regulation modules based on gene expression data
    Authors: 洪炯宗
    Contributors: 國立中央大學資訊工程系
    Keywords: 資訊科學;軟體
    Date: 2013-12-01
    Issue Date: 2014-03-17 14:16:49 (UTC+8)
    Publisher: 行政院國家科學委員會
    Abstract: 研究期間:10208~10307;In this project, we propose an analysis flow to combine genome databases, analysis tools and methods to identify transcription factors, regulation targets and relationship between transcription factors and targets. We plan to collect gene expression profiles and to examine dependency between a transcription factor and feasible regulation targets. Several positive samples contains transcription factor and its known regulation targets are successful identified in our pilot study. This system can also report a group of genes potentially regulated by the transcription factors. The putative targets are also verified by biological experiments in our pilot study. We will also develop an approach to identify regulation partners that cause of the differentially regulation in different cell-lines. The approach will use discriminate analysis to build classification models and select discriminate transcription factor from the discriminate models to be the candidates the regulation partner in the regulation module. In our pilot study in liver cancer cell-lines, several putative cofactors are known related to various cancers. It shows the proposed approach is sufficient to identify regulation module and regulation targets. In this project, we will completely examine the proposed approaches at first. Then we will develop a system to identity regulation modules and downstream regulation targets based on the proposed approach.
    Relation: 財團法人國家實驗研究院科技政策研究與資訊中心
    Appears in Collections:[資訊工程學系] 研究計畫

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML175View/Open


    All items in NCUIR are protected by copyright, with all rights reserved.

    社群 sharing

    ::: Copyright National Central University. | 國立中央大學圖書館版權所有 | 收藏本站 | 設為首頁 | 最佳瀏覽畫面: 1024*768 | 建站日期:8-24-2009 :::
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback  - 隱私權政策聲明