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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/6317


    Title: 分子內Michael 加成反應之非鏡像立體選擇性探討與天然物(-)-Allosedridine 和 (-)-2’-epi-Ethylnorlobelol 之合成 Total Synthesis of (-)-Allosedridine and (-)-2’;-epi-Ethylnorlobelol by Diastereoselective Intramolecular Michael Addition
    Authors: 陳俐如;Li-ju Chen
    Contributors: 化學研究所
    Keywords: Michael加成反應;非鏡像立體選擇性;(-)-2'-epi-Ethylnorlobelol;(-)-Allosedridine;diastereoselectivity;Michael addition
    Date: 2007-12-06
    Issue Date: 2009-09-22 10:17:29 (UTC+8)
    Publisher: 國立中央大學圖書館
    Abstract: 在本篇論文中,我們利用掌性苯乙胺及其衍生物來控制7-氯-2-庚烯甲酯進行分子內Michael 加成反應時之非鏡像立體選擇性,並且也研究(R)- α-苯乙胺加成至不同官能基之Michael acceptor 時,包括酯類、酮類和Weinreb 醯胺,其非鏡像立體選擇性的差異。最後,並將其應用來合成天然物(-)-allosedridine 和(-)-2'-epi-ethylnorlobelol。 In this thesis, we apply the chiral methylbenzylamine and their derivatives to control the diastereoselectivity of the methyl 7-chlorohept-2-enoate in intramolecular Michael addition reactions. And we also study the differences of the diastereoselectivity when (R)-α-ethylbenzylamine reacts with different Michael acceptors, including the ester, ketone and Weinreb amide. Finally, we apply this methodology to synthesize two natural products (-)-allosedridine and (-)-2'-epi-ethylnorlobelol.
    Appears in Collections:[化學研究所] 博碩士論文

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