微液滴成型晶片與其奈微米生醫工程應用之研究;Microfluidic Droplet Chip and Its Application in Biomedical Engineering

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题名:	微液滴成型晶片與其奈微米生醫工程應用之研究;Microfluidic Droplet Chip and Its Application in Biomedical Engineering
作者:	曹嘉文
贡献者:	國立中央大學機械工程學系
关键词:	電子電機工程;醫學工程
日期:	2012-12-01
上传时间:	2014-03-17 14:25:36 (UTC+8)
出版者:	行政院國家科學委員會
摘要:	研究期間：10108~10207;We propose a novel droplet-based microfluidic system. The microdroplets were generated from two immerscible fluid streams and disperse in the microchannel. Compare with continuous microfluidic system, droplet-based microfluidic system provides lots of unique advantages and can be used in the biomedical or chemical reaction applications. In this research proposal, we propose using droplet-based microfluidic system to use in cell culture and mass spectrometry interfacing application. In cell culture application, the microdroplet chip can efficiently separate the continuous fluids into individual droplets. Each droplet represent as a single cell culturing chamber. Thus, cell can be cultured in a high-throughput format without cross-contamination issues. In mass spectrometry analysis application, the droplet size represent as interfacing resolution. Using droplet-based microfluidic chip, the continuous-phase analyte can be diced into extremely small microdroplets and inject into the mass spectrometry target plate for following mass spectrometry analysis. The droplet formation mechanism and the microchannel design will need to further explore. Therefore, in this proposal, we use numerical simulation analysis to design the microchannel and experimentally evaluate the microdroplet chip performance.
關聯:	財團法人國家實驗研究院科技政策研究與資訊中心
显示于类别:	[機械工程學系] 研究計畫

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