許多市面上的醫療用藥已經被開發來針對G-蛋白偶合接受體 (GPCRs) 的功能來做調控。為了便利醫學和製藥的研究，我們開發了一個命名為RINGdb的新整合型生物資料庫來提供廣泛和組織過的G-蛋白偶合接受體與G-蛋白訊號調控蛋白 (RGS) 的資訊。在這個資料庫中，特定關於突變 (Mutation) 、組織分佈 (Tissue Distribution) 、蛋白質間的交互作用 (Protein-Protein Interaction) 、疾病/失調 (Diseases/Disorders) 、G-蛋白偶合接受體與G-蛋白訊號調控蛋白之間的關係等等的資訊是從許多文獻收集而來，而這些資訊和其他資料庫相比是獨一無二的。除此之外，RINGdb提供各式各樣對使用者友善的查詢功能來回答許多關於G-蛋白偶合接受體與G-蛋白訊號調控蛋白的問題，例如：他門促成某些疾病發生的可能性、他們在哪些組織共同表現、在G-蛋白訊號調控蛋白上除了最主要的功能區域 (Domain) 外，其他非G-蛋白訊號調控蛋白功能區域的潛在功能、哪些蛋白質可能會和G-蛋白訊號調控蛋白結合等等，並提供相關的統計數值來協助過濾出比較可能的結合蛋白。此資料庫也整合了組織好的資料庫交叉參考(Database Cross-Reference)，讓使用者可以直接獲得細部的資訊。這個知識庫將會有益於醫學研究、藥物開發、G-蛋白訊號調控蛋白和其它蛋白資交互作用的研究以及未來G-蛋白偶合接受體訊號傳遞路徑(GPCR Signaling Pathway)的模擬。 Many marketed therapeutic agents have been developed to modulate the function of G-protein coupled receptors. To facilitate clinical and pharmacological research, we develop a novel integrated biological database called RINGdb to provide comprehensive and organized RGS/GPCR information. In RINGdb, information with respect to mutation, tissue distribution, protein-protein interaction, diseases/disorders, and the RGS/GPCR relationship are collected from various literature surveys and the result is unique by comparing other databases. In addition, RINGdb offers various user-friendly query functions to answer different questions about RGS/GPCR such as their possible contribution to disease processes, in which tissue they are expressed together, the potential function of the non-RGS domain, putative RGS binding partners and so on and provides statistical values to filter putative RGS binding partners. It also integrates organized database cross-referencing to allow users direct access to detailed information. This knowledge base will be very useful for clinical research, drug discovery, the study of RGS/other binding partner interactions and for future GPCR signaling pathway modeling.
