本研究利用銅觸媒催化直接碳-氫鍵芳香環化反應，合成了一系列以TPD為主體結構之π共軛有機材料分子，不但降低了實驗成本且減少了反應所需時間，為一符合原子與步驟經濟效應之新合成途徑，相信能夠逐漸取代傳統交叉耦合反應並幫助我們更有效率地製備出所需之π共軛有機材料分子。 ;A series of thieno[3,4-c]pyrrole-4,6-dione (TPD)-based functional small molecules were efficiently synthesized through direct C-H arylations using inexpensive copper salts. In this study, we examined all required reaction parameters including various copper complexes, ligands, bases, and (co)solvents. Under the optimum reaction conditions, the C-H arylation proceeded smoothly and a variety of functional groups such as ester, nitrile, fluoride, chloride, triazene, and amine were tolerated. This method provides a step-economical and low-cost synthetic alternative to presently used coupling reactions for the preparation of TPD-containing π-functional materials.
