無鎳鋯基及鈦基金屬玻璃生物相容性之研究;Biocompatibility study of Ni-free Zr-base and Ti-base metallic glasses

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题名:	無鎳鋯基及鈦基金屬玻璃生物相容性之研究;Biocompatibility study of Ni-free Zr-base and Ti-base metallic glasses
作者:	張順富;Chang,Shun-fu
贡献者:	機械工程學系在職專班
关键词:	無鎳鋯基金屬玻璃;無鎳鈦基金屬玻璃;生物相容性;小鼠纖維母細胞;Ni-free Zr-base metallic glass;Ni-free Ti-base metallic glass;Biocompatibility;Murine Fibroblast
日期:	2014-07-29
上传时间:	2014-10-15 17:17:56 (UTC+8)
出版者:	國立中央大學
摘要:	醫療植入物因需長期使用，安全性及可靠性是產品的首要條件。金屬玻璃因其優異的機械性質、耐蝕性、抗菌性與良好的生物相容性，近年來許多學者開始進行將其應用於醫療器械的相關研究。本研究以真空吸鑄法成功製備出Zr42Cu42Al8Ag8、Zr48Cu36Al8Ag8及Ti40Zr10Cu36Pd14無鎳金屬玻璃，分別利用EDS、XRD、AFM進行成份定量分析、晶體結構以及表面形貌觀察。無鎳金屬玻璃均為非晶結構，其表面粗糙度皆在2.68 nm以下。為評估無鎳金屬玻璃的生物相容性，將小鼠纖維母細胞株L929培養於金屬玻璃上進行觀察細胞貼附於金屬玻璃之型態、細胞毒性測試與金屬離子釋出對細胞影響之分析。其中以Ti40Zr10Cu36Pd14無鎳金屬玻璃生物相容性表現最佳，無論在細胞培養直接接觸法或MTT assay均證實不具有細胞毒性；細胞貼附實驗結果顯示細胞易於生長且細胞膜延展佳，與現行醫療用鈦合金(Ti-6Al-4V)有相似的表現；且其無鎳的成份及極低銅離子溶出比現有醫療用合金具有更良好的生物相容性。 ;Safety and reliability are crucial issues to medical instruments and implants. In the past few decays, bulk metallic glass draw lots attentions due to their excellent mechanical properties, good corrosion resistance, antibacterial and good biocompatibility, and were considered as an ideal candidate for medical related implants. Three Ni-free bulk metallic glasses include the Zr42Cu42Al8Ag8, Zr48Cu36Al8Ag8 and Ti40Zr10Cu36Pd14 were studied and evaluated their potential as medical implants. The glassy nature and composition of these three bulk metallic glasses were firstly confirmed by X-ray diffraction analysis and energy dispersive spectrometer. The surface roughness examined by atomic force microscope, all samples perform nano-meter-scale surface roughness. Several biocompatibility tests were carrying out to evaluate these three bulk metallic glasses co-cultural with L929 murine fibroblast cell line. The results of cellular adhesion behavior, cytotoxic, and metallic ion release affection. The optima biocompatibility results occur at Ti40Zr10Cu36Pd14 bulk metallic glass, cell still attached on the petri dish with good adhesion and exhibit the spindle shape after direct contact test. Furthermore, the Ti40Zr10Cu36Pd14 sample showed the lowest Ni and Cu ion release level which correlate to MTT results. Based on the data mentioned above, we believe that Ti40Zr10Cu36Pd14 bulk metallic glass can be one of ideal candidates for medical implant materials.
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