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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/69154

    Title: 冷凍成型積層製造之機台設計與組織工程支架製作參數調校研究;Design of Frozen-form Fabrication System and Manufacturing Parameters Tuning of Scaffolds for Tissue Engineering
    Authors: 林研聖;Lin,Yen-sheng
    Contributors: 機械工程學系
    Keywords: 組織工程;組織工程支架;積層製造;冷凍成型積層製造
    Date: 2015-08-27
    Issue Date: 2015-09-23 15:30:21 (UTC+8)
    Publisher: 國立中央大學
    Abstract: 組織工程支架在組織再生以及器官再造上,扮演了相當重要的角色。本研究利用冷凍成型積層製造法製作組織工程支架,其方法的最大特色為當支架製作完成時,能以冷凍乾燥的方式昇華支架內含的水分,使支架表面留下微小孔隙以利於後續的細胞培養。
    ;The Scaffolds of tissue engineering plays a important role in tissue regeneration and organ creation. This research used Frozen-form Fabrication to manufacture scaffolds. The characteristic of this additive manufacturing technique is using the freeze-drying method to sublimate ice in the scaffolds. It will remain micro-pores around scaffold’s surface. These micro-pores are very beneficial for cell culture.
    The purposes of this research were designing Frozen-form Fabrication system and measuring the widths of scaffolds’ filaments which were used different manufacturing parameters to deposit.
    Frozen-form Fabrication system was used a SCARA and a Z-axis stage, which are independent to each other. The Z-axis stage will descent a height of layer immediately after a layer of material had been deposited. Then the system will be deposited next layer until the whole scaffold was finished. Every layer of scaffold will be deposited in the same height, so that each layer of scaffold will be deposited in the same and uniform temperature environment.
    Regarding the measurement of the widths for scaffolds’ filaments, we changed parameters of extrusion pressure and nozzle moving speed to compare the differences of filament’s width and flatness of the structure. SEM images can help us observe filaments width clearly. Finally, we will make some figures to compare the filaments width and observe the trend.
    Appears in Collections:[機械工程研究所] 博碩士論文

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