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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/69195

    Title: 頻域式擴散光學造影之乳房掃描暨量測系統研究
    Authors: 游釗銘;Yu,Jhao-Ming
    Contributors: 光機電工程研究所
    Keywords: 近紅外光擴散光學成像;三維環形掃描;頻域式光學量測;俯臥式;mZnS;光學係數影像;仿乳假體驗證;NIR DOI;3-D ring-scanning;mZnS;prostrate-type;frequency-domain measurement;optical-property images;phantom experiment
    Date: 2015-10-01
    Issue Date: 2015-11-04 17:21:09 (UTC+8)
    Publisher: 國立中央大學
    Abstract: 近紅外光擴散光學成像(near infrared diffuse optical imaging, NIR DOI)是新穎的功能性醫學造影技術,其檢測機制乃藉個別組織(如皮膚、脂肪、及腦灰質等)光學特性差異,以及病變組織血紅素濃度增加、含氧飽和程度降低等,致NIR特定波段的光吸收、散射特性有所差異,以此區分組織之變異狀況。因台灣乳癌發生率及死亡率逐年提升,且基於早期發現對治療及預後有正面幫助,故本研究藉由設計三維環形掃描裝置,結合頻域式光學量測技術,建立應用於乳癌檢測之俯臥式擴散光學斷層掃描造影系統。
    ;Breast cancer has long-term remained the highest incidence rate, and the 4th highest mortality rate for woman in Taiwan. Based on routine X-ray breast mammography, relatively safe near infrared diffuse optical imaging (NIR DOI) is emerging as a potential imaging technique for breast cancer detection. Compared with the mammography which gives only the structural images of breast tissue, DOI provides not only the structural information, but also the functional images including oxyhemoglobin, deoxyhemoglobin, lipid and water content as well as the morphological images including nucleus size and volume fraction. This research project aims to obtain structural, functional and morphological contents of breast tissue using a multi-spectral DOI image reconstruction approach.
    In this study, we propose and implement three-dimensional (3-D) ring-scanning equipment for near-infrared (NIR) diffuse optical imaging to screen breast tumors under prostrating examination. This equipment has the function of the radial, circular, and vertical motion without compression of breast tissue, thereby achieving 3-D scanning; furthermore, a flexible combination of mZnS design of illumination and detection can be configured for the required resolution. The research proceeds to the development of prostrate-type DOI system based on previous basis, such as frequency-domain measurement system, inverse computation scheme for optical-property images, and algorithms for the purpose of rapid convergence, edge-preserving for better tumor detection. Results of this study showed phantom experiment confirmed that the 3-D scanning system can distinguish the geometric and optical characteristics difference between tumors and background.
    Appears in Collections:[光機電工程研究所 ] 博碩士論文

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