探討與MAPK/ERK 訊息傳遞相關之新穎微型RNA 在訊息傳遞之調控及對黑色素瘤的作用;Exploration of Novel MAPK/ERK Related microRNAs in Regulation of MAPK/ERK Signaling Pathway and Their Functional Effects in Melanoma

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Title:	探討與MAPK/ERK 訊息傳遞相關之新穎微型RNA 在訊息傳遞之調控及對黑色素瘤的作用;Exploration of Novel MAPK/ERK Related microRNAs in Regulation of MAPK/ERK Signaling Pathway and Their Functional Effects in Melanoma
Authors:	馬念涵;呂仁
Contributors:	系統生物與生物資訊研究所
Keywords:	訊息傅遞路徑;_x000d_ 微型RNA;_x000d_ 腫瘤;_x000d_ 黑色素瘤;生物標記;Signaling transduction;Tumor progression;MAPK/ERK signaling;_x000d_ microRNA;melanoma;Biomarkers;基礎醫學;生物技術(醫)
Date:	2016-03-29
Issue Date:	2016-03-30 11:12:04 (UTC+8)
Publisher:	科技部
Abstract:	近來微型RNA (MicroRNAs or miRNAs)已被證明是轉錄後基因表現的主要調節者，微型 RNA表現不正常也影響許多疾病的產生。此外，在現今的研究中指出，比起傳統mRNA 表現為基礎架構來分辨癌症，微型RNA是為更有效率的分類依據。因此，微型RNA很有機會成為未來新穎癌症的指標，及用於癌症治療。Ｍitogen-activated protein kinase (MAPK/ERK) 訊息傳遞路徑的活化與許多細胞癌化息息相關。例如高達百分之六十以上在黑色素瘤細胞中發現有MAPK/ERK訊息傳遞;MicroRNAs (miRNAs) have emerged as key post-transcriptional regulators of gene expression in human. Recent studies reported that miRNAs profiles are more effective in cancer classification than mRNA profiles, indicating that miRNAs would be better and nov;研究期間：10408~10507
Relation:	財團法人國家實驗研究院科技政策研究與資訊中心
Appears in Collections:	[Institute of Systems Biology and Bioinformatics] Research Project

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