乳房組織光學係數量測 暨資料庫建立之研究

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题名:	乳房組織光學係數量測暨資料庫建立之研究
作者:	吳浚晟,;Wu,Chun-Cheng
贡献者:	光機電工程研究所
关键词:	雙積分球系統;乳房組織光學特性;吸收係數;散射係數;Double integrating sphere system;Optical Characteristics of Breast Tissue;Absorption Coefficient;Scattering Coefficient
日期:	2016-03-17
上传时间:	2016-06-04 12:37:04 (UTC+8)
出版者:	國立中央大學
摘要:	根據行政院衛生福利部國民健康署指出女性罹患乳癌的發生率為所有癌症之首，而其死亡率也高居癌症中的第四位；而統計數據指出第0期乳癌的5年存活率高達97.70%。因此發展一個能夠安全且有效的診斷方式是一個重要的課題。實驗室近十年致力於發展近紅外光擴散光學斷層影樣（Near-infrared Diffuse Optical Tomography, NIR-DOT）系統，其檢測機制是藉由組織在近紅外光下光學特性的差異來辨別正常與腫瘤組織。本研究著重於開發直徑300 mm雙積分球量測系統，用以建立乳房組織光學資料庫；系統建構包括元件特性測試、實驗流程設計及系統因子分析等。確定本系統之穩定性，另藉由光學特性假體、豬皮及脂肪層的量測，確認此系統的可靠性。研究中在三軍總醫院，完成人體乳房組織切片樣本之光學特性測定；另配合病理部之切片病理分析報告，進而逐步建立台灣婦女乳房組織之光學資料庫，並藉由此資料庫之數據，完成以組織光學特性判斷組織病變如侵襲癌、原位癌及纖維組織增生之特性。根據實驗量測結果具體得知，癌變組織相對於正常組織，吸收的對比度(contrast)約為2.00±1.28倍，而散射係數對比度約為1.37±0.35倍。更進一步可以藉由癌變組織的吸收係數判斷癌變組織狀態，侵襲癌相對於正常組織的吸收的對比度約為1.50±0.50倍，而原位癌之吸收對比度約在4.13±1.43倍。而散射部分可以判斷癌變組織有無纖維組織的增生及鈣化，無纖維組織增生及鈣化之腫瘤組織相對於正常組織的散射係數的對比度約為1.19±0.22倍，而有無纖維組織的增生及鈣化散射對比度約在2.06±0.99倍。因此，藉由生理組織之光學特性，可作為判斷組織病變的重要指標。 ;The incidence rate and mortality rate of breast cancer is ranked first and fourth in Taiwan respectively, and statistical data indicate the 5-year survival rate of stages 0 breast cancer was 97.70%. Therefore, the development of a safe and effective diagnostic modality is an important issue. Our laboratory developed near-infrared diffuse optical tomography (NIR-DOT) system, it distinguished normal tissue and tumor tissue by the optical characteristics. The research developed ∅ 300 mm double integrating sphere measurement system to establish an archive for optical coefficients of breast tissue. We confirm the stability of system by element characteristic test, experimental process design and system factor analysis. Measuring the optical characteristics of the phantom, pigskin and fat to confirm reliability of this system. We conducted clinical trial at the Tri-Service General Hospital (TSGH), and measured optical characteristics of breast tissue biopsy and correseonded sliced pathological analysis report to gradually establish an archive for optical coefficients of breast tissue in Taiwan. According to the archive, we odtain optical characteristics of tissue to determine tissue lesions such as infiltrating carcinoma, carcinoma in situ and fibroblasts proliferation. Based on test results, We acquired absorption coefficeut (μa) and scattering coefficient (μs′) from breast tissue biopsy. We compared tumor tissue to normal tissue with the contrast of μa is 2.00 ± 1.28 and μs′ is 1.37 ± 0.35. Furthermore, the μa of tumor separated infiltrating carcinoma and carcinoma in situ, and the contrast is 1.50 ± 0.50 and 4.13 ± 1.43. The μs′ of tumor can determine that there is the fibroblasts proliferation or not, and the contrast is 1.19 ± 0.22 and 2.06 ± 0.99. Because of the optical characteristics of the physiological tissue, it is used as an important indicator of tissue lesions.
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