English  |  正體中文  |  简体中文  |  Items with full text/Total items : 73032/73032 (100%)
Visitors : 23024750      Online Users : 492
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/71419

    Title: 抑制酸敏感受體TDAG8或ASIC3基因表現降低坐骨神經慢性壓迫性損傷所誘發的機械性痛覺過敏現象;Inhibition of TDAG8 or ASIC3 gene expression reduces mechanical hyperalgesia induced by chronic constriction injury of the sciatic nerve
    Authors: 鄧志宇;Teng,Chih-Yu
    Contributors: 生命科學系
    Keywords: 酸敏感受體
    Date: 2016-07-26
    Issue Date: 2016-10-13 13:03:15 (UTC+8)
    Publisher: 國立中央大學
    Abstract: 根據全球市場調查從2007年到2015年全球將會有1.5億人將受到長期性疼痛所困
    ;According to global market analysis in 2007-2015, 1.5 billion people suffer from chronic pain with 3-4.5 % of population in neuropathic pain. The treatment of neuropathic pain continues to be a major management challenge in clinical practice. Understanding of the molecular mechanism of neuropathic pain is essential to identify potential drug targets for clinical treatments. Previously mice with neuropathic pain showed allodynia for 8 days, and ASIC3 immunoreactivity is up-regulated in DRG neurons. In other studies, neutrophils around the injury site increases substantially within 8 hours, and peaks at 24 hours. These studies suggest that the local inflammation of peripheral nerves and proton-sensing genes may play an important role in neuropathic pain. In this study, I used the model of peripheral mononeuropathy by chronic constriction injury (CCI) of the sciatic nerve, we have found that CCI mice developed long-term (at least 4 month) mechanical hypersensitivity and inflammation. Nerve degeneration was also found. We then generated TDAG8 knockdown(KD) and ASIC3 knockout(KO) mice to study the roles of the genes in neuropathic pain. We found that knockdown of TDAG8 delayed the onset of mechanical hyperalgesia induced by CCI. ASIC3 KO mice inhibited the late phase of CCI-induced mechanical hyperalgesia. Granulocytes cells were increased in TDAG8 KD mice in the first two weeks of CCI. Macrophages were decreased in ASIC3 KO mice in the late phase of CCI.
    Appears in Collections:[生命科學研究所 ] 博碩士論文

    Files in This Item:

    File Description SizeFormat

    All items in NCUIR are protected by copyright, with all rights reserved.

    社群 sharing

    ::: Copyright National Central University. | 國立中央大學圖書館版權所有 | 收藏本站 | 設為首頁 | 最佳瀏覽畫面: 1024*768 | 建站日期:8-24-2009 :::
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback  - 隱私權政策聲明