表面增強拉曼散射 (SERS) 於近幾年已發展成為一個超靈敏的檢測分析工具，並用於各種不同的領域，但是要邁向商品化最大的挑戰為穩定的製程以及如何製作具有高再現性、高穩定度、高靈敏度且可重複使用的SERS基板，因此本研究致力於使用具有高介電常數的CoTiO3作為基板進一步提升SERS的增強效果。 本研究利用靜電紡絲法 (Electrospinning method) 經由不同退火溫度製作CoTiO3/Ag複合奈米纖維，探討其SERS效應，結果顯示經過退火700℃後的奈米纖維表面有明顯的奈米銀顆粒，當入射光照射時會在金屬表面產生表面電漿共振並形成高度增強的近場，拉曼散射光也因此增強數十至數百倍，所以有最強的SERS強度，其SERS強度與濃度呈線性關係，可用來做未知濃度的測定，且本研究製作的SERS基板具有可靠度，並可經由去離子洗滌後重複使用。最後我們進一步將CoTiO3/Ag複合奈米纖維製備成具有較高機械強度的螺旋結構，降低奈米銀顆粒之間的距離以增強SERS效果並提高實用性。;In recent years, surface-enhanced Raman scattering (SERS) has become an ultrasensitive analytical tools, which could be widely applied in various fields. However, the major challenge of towards commercialization is to establish a reliable and reusable SERS-active substrates with high reproducibility, and sensitivity. Taking the above considerations into account, this study focus on the fabrication of CoTiO3/Ag composite nanofibers and study on their SERS performances. In this study, we fabricate CoTiO3/Ag composite nanofibers by using the electrospinning method. We also compare the SERS activities of CoTiO3/Ag-nanofiber substrates which were annealed at different temperatures. The results show that Ag nanoparticles were obviously formed on the nanofibers after annealing at 700℃, showing the highest SERS performance. This is because when the irradiation of incident light causes the surface plasma resonance on the metal surface and forms a highly enhanced near-field, leading to the enchantment of Raman scattering intensity by times of tens to hundreds. Since its SERS intensity and concentration exhibits a linear relationship, it can be used to determine the measuring concentration. We also find that the resulting SERS-active substrates are uniform and can be reused after being washed only by deionized water. Finally, we further twist nanofibers to form the helical structure with high mechanical strength. It not only reduces the distance between Ag nanoparticles to enhance the SERS performance, but also increases their mechanical strength to be widely applied for more applications.
