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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/71649

    Title: 藉由疾病網路和基因共表達網路分析阿茲罕默症和第二型糖尿病;Analysis of disease and gene co-expression networks of Type 2 diabetes and Alzheimer’s diseases
    Authors: 張翃;Hung-Chang
    Contributors: 系統生物與生物資訊研究所
    Keywords: 疾病網路;基因共表達網路;阿茲罕默症;第二型糖尿病;disease network;gene co-expression network;Alzheimer’s diseases;Type 2 diabetes
    Date: 2016-07-27
    Issue Date: 2016-10-13 13:25:04 (UTC+8)
    Publisher: 國立中央大學
    Abstract: 老化常伴隨一些常見疾病,例如:白內障、第二型糖尿病、阿茲海默症和高血壓…等。第二型糖尿病為常見的一種代謝性疾病,約占糖尿病診斷90~95%的病例。阿茲海默症則是癡呆的常見原因,並且導致心血管疾病,例如: 冠狀心臟疾病、中風、糖尿病和高血壓…等。儘管有許多研究指出阿茲海默症的潛在危險因素,但此病在流行病學的研究尚未清楚。
    ;Aging often accompanied with some common diseases like Cataract, type 2 diabetes (T2D), Alzheimer’s disease (AD), and hypertension. T2D is a common of metabolic disorders, and accounts for about 90–95% of diagnosed cases of diabetes. AD is most common cause of dementia, and it is also more frequently related cardiovascular diseases such as coronary heart disease, stroke, diabetes mellitus and hypertension. In spite of such research efforts the underlying risk factors, epidemiologic and progression of AD are not well clear.
    An issue of interest is the comorbidity of AD and T2D, respectively between each other and with other diseases. Known pathophysiological factors shared by AD and T2D include insulin, cholesterol, β-amyloid aggregation and tau. Recently, evidences connecting AD to impaired function of insulin/IGF and suggest AD might be a new type of “type 3” diabetes.
    In this work, we gain insight into possible new connections between Alzheimer’s disease (AD) and type 2 diabetes (T2D) by taking a systems approach. First, we focus on AD and T2D patient′s information and on related diseases, and identifying and analyzing changes in both of disease network that can be attributed to comorbidities are disjoint. Second, we identify gene-pairs that are inverse connections between brain region-specific ADs and tissue-specific T2Ds through gene co-expression networks. More specifically, we aim to integrate information related to risk, trend, and possible prevention and treatment of AD and T2D.
    Appears in Collections:[系統生物與生物資訊研究所] 博碩士論文

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