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    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/72871

    Title: 開發心肌缺氧後再灌流傷害用藥與近紅外光染劑的高效率微脂體包覆方法
    Authors: 余序恩;Yu, Xu-En
    Contributors: 化學學系
    Keywords: 微脂體;藥物包覆
    Date: 2017-03-06
    Issue Date: 2017-05-05 17:10:44 (UTC+8)
    Publisher: 國立中央大學
    Abstract: 本研究開發微脂體以主動包覆方式包覆數種醫學上重要的藥物及化合物。其中被包覆物聚焦在治療心肌細胞受損(缺氧後再灌流)的藥物與近紅外光螢光染劑。
    心肌缺氧後再灌流(reperfusion)對心肌的再傷害為心臟病治療一棘手問題。目前臨床上治療此傷害的方式為投放藥物治療。但由於藥物生物分布選擇性差,造成藥效降低,所以選擇性將治療再灌留藥物集中分布到受損心肌以提高藥物被利用的效果為治療的重要課題。本實驗為開發新藥物及化合物的微脂體主動包覆的方法為主。嘗試各種不同trapping agent的鹽類梯度,利用主動包覆的方法,提升大部分的藥物被包覆於微脂體內之機率及包覆效率。以供後續團隊可嘗試證實此類微脂體藥物治療心肌受損的可行性。
    ;My thesis work is to develop active (remote) loading methods for encapsulating (1) myocardial reperfusion injury drugs and (2) near infrared dyes (for in vivo imaging) into liposomes.
    Reperfusion injury might be treated if we can spatial-selectively deliver the drug to the reperfusion area and rapidly unload the drug before irreversible damage occurs. This work is a sub-project that focuses on the development of highly efficient content encapsulation of liposome using active loading approach. We have screened and found several trapping agents / drug pairs that can offer high loading efficiency.
    The second part of this work is, instead of loading myocardial infarction drugs, to encapsulate near-infrared (NIR) dyes for the detection of liposomal triggered release, in live small animal and in real time fashion. At present, dye encapsulated liposome in vivo imaging studies only allow us to see the biodistribution of liposome. To the best of our knowledge, liposome triggered-release that can be fluorescently visualized in small animal has not been reported yet. In the second project, we also tried to screen many pairs of trapping agents and NIR dyes to identify the best combination for NIR dye-encapsulated liposome in which the dye concentration is high enough for fluorescently self-quenched. In the future, hopefully we can use the fluorescent reporting, dye-encapsulated liposome to confirm the liposomal triggered release in small animal level.
    Appears in Collections:[化學研究所] 博碩士論文

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