可見光催化氨基酸與萘酚進行 C(sp3)-C(sp2) 耦合與三牙基含氮雙烯鈀金屬錯合物在鈴木反應中之研究;C(sp3)-C(sp2) Coupling Between Amino Acids and Naphthols by Photoredox Catalysis and Pincer Carbodicarbene Palladium Complex in Suzuki Cross Coupling

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題名:	可見光催化氨基酸與萘酚進行 C(sp3)-C(sp2) 耦合與三牙基含氮雙烯鈀金屬錯合物在鈴木反應中之研究;C(sp3)-C(sp2) Coupling Between Amino Acids and Naphthols by Photoredox Catalysis and Pincer Carbodicarbene Palladium Complex in Suzuki Cross Coupling
作者:	陳英和;Chen, Ying-Ho
貢獻者:	化學學系
關鍵詞:	可見光;催化;鈀金屬;同碳雙碳烯;耦合;visible light;catalysis;palladium;carbodicarbene;coupling
日期:	2017-07-11
上傳時間:	2017-10-27 12:56:16 (UTC+8)
出版者:	國立中央大學
摘要:	摘要近年來，可見光氧化還原催化劑已被廣泛的應用在有機反應。相較於傳統的加熱反應，光催化可在較為溫和條件進行反應，並且可使用無害的可見光作為能量來源。在本研究中，成功利用可見光催化胺基酸與萘酚進行碳 (sp3)-碳(sp2) 的去羧酸耦合。相較於文獻的結果，此論文所發展的光催化反應可在較溫和的條件下進行，並且對於氨基酸與萘酚的官能基有更大的耐受性。另外，實驗室先前所合成的的同碳雙碳烯鈀金屬錯合物具有光學性質，意外的也具有光催化反應的效果。在本篇論文中我們探討此錯合物在鈴木反應上的反應性，成功證明其不僅可以進行可見光催化也可以進行有機金屬催化。;ABSTRACT Photoredox catalyst has been widely developed to use visible light sources in the organic synthesis recently. A synthetic paradigm using photoredox catalyst has offered many advantages compared to conventional synthetic method based on heating process. For example, the reactions can proceed under mild conditions at ambient temperature. In this thesis work, we have developed a catalytic photoredox reaction for C(sp3)-C(sp2) coupling of naphthols with amino acid through decarboxylative reaction. The coupling reaction was successfully applied to a range of substrates of tertiary amino acids and naphthols under mild condition. In second part of thesis, we discovered that the pincer carbodicarbene palladium complex has optical properties and acts as photoredox catalyst. We studied the reactivity of pincer carbodicarbene palladium complex in Suzuki- Miyaura cross-coupling reactions. We successfully proved that this catalyst not only served as photocatalyst but also be cross coupling catalyst.
顯示於類別:	[化學研究所] 博碩士論文

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