在文獻回顧中，冷卻結晶、蒸發結晶以及反溶劑結晶法為分離及純化常見之技術，但多為各別探討，較少文獻針對此三種結晶製程合併及放大規模的討論。因此，此份計畫書的研究有三大主要目標：(1)找出各個結晶製程之最佳操作條件，以及比較此三種結晶製程的特性；(2)藉由使用溶液篩選法來發展對於高溶解度分子具有再現性之結晶製備程序，由冷卻結晶、蒸發結晶以及反溶劑結晶法共同組成；(3)將0.5 L最佳化的合併製程結果應用於5 L結晶槽的放大研究，並建立出不同尺度間之關聯性。 ;The cooling, evaporative and anti-solvent crystallization are common techniques used in the purification and separation process, and have been well-studied separately in the literatures. However, there is few study relate to the combination of three crystallization processes and scaling up this process. Therefore, the aim of our research proposal is threefold:(1) to obtain the most effective parameters for each method and the comparison among cooling, evaporative, anti-solvent crystallization processes,(2) to develop a reproducible production of highly soluble compounds for the combined process of cooling, evaporative, anti-solvent crystallization by using initial solvent screening method, and(3) to scale up the optimized production from 0.5 L to 5 L for constructing the correlations for the process development.
