English  |  正體中文  |  简体中文  |  Items with full text/Total items : 75369/75369 (100%)
Visitors : 24722190      Online Users : 238
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/7838

    Title: 以2D HP 模型對蛋白質摺疊問題之研究;A Study on the Protein Folding Problem in the 2D HP Model
    Authors: 呂永志;Yung-chih Lu
    Contributors: 數學研究所
    Keywords: 蛋白質摺疊;uniqueness of protein folding
    Date: 2004-06-08
    Issue Date: 2009-09-22 11:06:47 (UTC+8)
    Publisher: 國立中央大學圖書館
    Abstract: 蛋白質在生物化學中扮演非常重要的角色,蛋白質的化學構造非常複雜,然而大多數生物學家相信蛋白質的摺疊方式是唯一的:將蛋白質拆解拉成一長串胺機酸序列後,蛋白質會在數微秒到數毫秒間恢復原狀。這個問題也一直是生物學家、化學家、物理學家爭論的焦點,然而一直得不到令各方信服的說法。近年來,數學家想以數學模型來模擬此一問題:”蛋白質摺疊的唯一性”。 本論文採用Dill於1985年依據能量觀點所提出的二維HP模型為基礎,討論蛋白質摺疊的唯一性的問題(Crescenzi等人已於1998年證明此一問題在二維HP模型下為NP-complete)。本論文分為三章:第一章,簡介蛋白質構造及摺疊問題。第二章,針對Norman於2002年所提出的演算法做出細部修正。第三章,討論由Brian Hayes於1998年所提出的問題:在二維HP模型下,什麼樣的蛋白質序列有唯一摺疊?本文以迥異於Brian Hayes的想法,提出並證明長度為4k+5時的序列型態。並推測長度為4k+3時,具唯一摺疊的序列。 There are three chapters in this paper. In chapter1, we introduce the structures of proteins and the HP model suggest by Dill in 1985. In chapter2, we consider a algorithm suggested by Alanthan Newman in 2002: It is a 1/3-approximation linear-time algorithm for the protein folding problem on the 2D square lattice. Unfortunately his proof was not sound and had gaps. We claim that there are a few blemishes in his analysis of the algorithm, and we are going to fix it. In chapter3, we consider a problem suggested by Brian Hayes in 1998: what proteins in the two-dimensional HP model have unique optimal foldings? In particular, we prove that there are (open chains) with the property for all lengths of the form 4k+5.
    Appears in Collections:[數學研究所] 博碩士論文

    Files in This Item:

    File SizeFormat

    All items in NCUIR are protected by copyright, with all rights reserved.

    社群 sharing

    ::: Copyright National Central University. | 國立中央大學圖書館版權所有 | 收藏本站 | 設為首頁 | 最佳瀏覽畫面: 1024*768 | 建站日期:8-24-2009 :::
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 隱私權政策聲明