在這個兩年的計畫中，我們將產出一全新的感測協定: 具有對映選擇性、高靈敏、高空間時間解析能力的比色法。針對前一期計畫的缺點，基於熔合雙奈米球的改良式感測探頭將被採用。根據邊界元素方法的模擬，單一超手徵場可以形成於雙奈米球表面重疊的尖端處。而伴隨著此手徵場之光學力可以對鏡像異構物產生具有吸引或排斥選擇性，完全取決於待測分子的掌性。飛秒雷射誘發電漿加熱效應將用來製作融合奈米雙球結構，而一自行開發具有電、光、熱耦合的遞迴運算程式則可提供如何選擇適當製程參數如：偏振方向及脈衝能量的知識。除了製作表面電漿陷阱，亦將發展一基於顏色編碼、無光譜儀的偵測方式。將系統引入一高速電荷耦合元件，因待測分子型態或奈米環境變化所致之色度變化可被連續即時偵測。就儀器的簡易性、即時偵測能力、及空間多點探測解析能力等方面比較之，此一感測系統將更勝於傳統基於光譜儀的感測器。在計劃的第二年，我們將更進一步延伸結果，構裝熔合雙奈米球於光纖端面上，目標是開發內視感測系統。預期結果將在科學界與工業界產生重大影響，特別是製藥、毒物鑑定、食安、及環境偵測等領域。 ;In this 2-year-project, a brand-new sensing protocol where enantioselective colorimetry with high sensitivity and spatial-temporal resolution will be delivered. Based on our previous track record, a revised nanostructure basing on merged double nanoparticles (MDNPs) will be used as the sensing probe. Simulation based on boundary element method (BEM) reveals that homo- and super-chiral field can be generated at the cusps of the overlapped surface. The associated discriminatory force can thereby attract or repel certain enantiomers depending on their handedness. The proposed structure will be fabricated by femtosecond laser induced plasmon heating and a home-built electro-opto-thermal algorithm provides the knowledge to select appropriate parameters such as polarization directions and pulse energies. In parallel to setting up the plasmonic trap, a spectrometer-free, color-coded detection scheme will be developed. By employing a high speed color CCD, the chromaticity variation as results of molecular conformation or nanoenvironment change can be continuously monitored in real time. The proposed sensing scheme is expected to outperform conventional spectrum based sensors in terms of instrumental simplicity, real-time capability, and additional spatial resolution which is very useful for multi-point detection.In Year 2, we will further extend the result to fabricate MDNPs on fiber ends, aiming at developing endoscopic sensing systems. It is expected that the results will produce substantial impact and benefit to the scientific society and industry, in particular to the field of pharmaceutics, drug/toxicant identification, food safety, and environment monitoring.
