本研究透過半流動式裝置在溫度為 308.2 K、318.2 K 與 328.2 K，壓力範圍為 10 ~22 MPa 的超臨界二氧化碳中量測鄰乙氧苯甲醯胺和 2–氯–4-硝基苯甲酸的溶解度，並透過紫外∕可見分光光度計進行定量分析。在上述的實驗條件下，溶解度數據是以不同的二氧化碳取樣流量進行三次獨立量測，其中二氧化碳的流量範圍為3 L/h ~ 9 L/h，並由此三次獨立量測的溶解度取平均值當作該固體溶質在操作條件下於超臨界二氧化碳中的溶解度，且三次溶解度的變異係數皆低於6%。本次量測鄰乙氧苯甲醯胺和 2–氯–4–硝基苯甲酸的溶解度莫耳分率範圍分別落在10-5 ~ 10-4 與10-6 ~ 10-4。最後在此研究中利用四個半經驗方程式：Chrastil 模型、Mendez-Santiago & Teja （MST）模型、Bartle 模型和 Kumar & Johnston（K-J）模型，對新量測的溶解度數據進行迴歸和自身一致性測試。其得到的迴歸結果，在四種模型的平均相對標準誤差（average absolute relative deviation, AARD）中，範圍落在 2.17%的 Chrastil 模型到 7.10%的 K-J 模型之間，並利用四種半經驗方程式作為溶解度數據的自身一致性檢測，檢測結果都有不錯的線性關係，足以驗證實驗量測數據之可靠性。;In this study, the solubilities of ethenzamide and 2-chloro-4-nitrobenzoic acid were measured in supercritical carbon dioxide at temperatures of 308.2 K, 318.2 K, and 328.2 K and in a pressure range of 10 ~ 22 MPa by a semi-flow type apparatus. The composition analysis was carried out by ultraviolet–visible spectroscopy. The solubility of the studied solid solute at a given experimental condition was measured three times independently with different carbon dioxide sampling flow rates, where the carbon dioxide flow rates ranged from 3 L/h to 9 L/h. The reported solubility result was the average value of these three independent measurements, and the coefficient of variation of the solubility was confirmed to be less than 6% for all three measurements. Finally, four semi-empirical equations were used in this study: Chrastil model, Mendez-Santiago & Teja (MST) model, Bartle model and Kumar & Johnston (K-J) model. Experimental data regression and self-consistency tests of these newly measured solubility data were conducted. The overall deviation in term of average absolute relative deviation (AARD) were in the range of 2.17% (Chrastil model) ~ 7.10% (K-J model) for the four studied models. The self-consistency tests were performed using the four semi-empirical models for the solubility data, and the results confirm the reliability of the experimental data.
