節能多晶型L-谷氨酸的晶體工程與乾燥性質研究;Crystal Engineering of the Energy-Saving Polymorph of L-Glutamic Acid for Drying

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題名:	節能多晶型L-谷氨酸的晶體工程與乾燥性質研究;Crystal Engineering of the Energy-Saving Polymorph of L-Glutamic Acid for Drying
作者:	楊佳翎;Yang, Chia-Ling
貢獻者:	化學工程與材料工程學系
關鍵詞:	節能;谷氨酸;乾燥;多晶型;結晶;Energy-Saving;L-Glutamic Acid;Drying;Polymorph;Crystallization
日期:	2021-08-03
上傳時間:	2021-12-07 11:16:54 (UTC+8)
出版者:	國立中央大學
摘要:	節能減碳是一個重要的全球性議題。其中乾燥程序在整個工業過程中即佔能源消耗的12％。因此，改善乾燥性能可以大幅降低能耗。然而與乾燥行為有關的多晶型物的信息很少。本研究的目的是探討不同的L-谷氨酸多晶型體對乾燥行為的影響，並藉由實驗設計(DoE)找出製備窄粒徑分布的α型L-谷氨酸晶體的方法。本研究第一部分為多晶型物的乾燥實驗。通過反應結晶分別製備了α-L-谷氨酸和β-L-谷氨酸的晶體，並將反應產物用於40°C乾燥實驗，記錄失重與時間的關係。可以發現，α-L-谷氨酸晶體具有較短的總乾燥時間。 β-L-谷氨酸晶體由於其晶體分子表面結構而更易於在其濾餅中保留水分。結果，α-L-谷氨酸晶體在乾燥過程中顯示出更好的節能性能，相較於β-L-谷氨酸可節省35%用於乾燥的能量。第二部分為製程設計，期能獲得均勻且足夠大的α-L-谷氨酸晶體。利用田口法尋找較佳的操作條件，選擇四項參數及三個水準，分別為(1) 1M硫酸水溶液的添加速度，(2)反應溫度，(3)反應槽攪拌速度，(4)添加物L-苯丙胺酸的濃度。根據回應表選擇適當的參數組合，以產生所需粒徑的α-L-谷氨酸。在四個參數中，反應溫度對系統穩定性影響最大，溫度越高，系統越容易受到其他條件的影響。此外，能得到最窄粒徑分布的組合為：1M硫酸水溶液的添加速度為1 mL/s，反應溫度為35℃，反應槽攪拌速度為500 rpm，添加物L-苯丙胺酸的濃度為5.20×10-2 M。這些資訊將有助於進一步放大製程。;Energy-saving is an important global issue. Drying, especially, occupies 12% of the energy consumption in the entire process in the industry. Therefore, improving the drying behavior could greatly reduce energy consumption. However, information on polymorphs related to drying behavior is missing. The purpose of this study is to investigate the effects of polymorphs of L-glutamic acid crystals on drying behavior, and to design a process to prepare pure α form L-glutamic acid crystals with uniform particle size. The first part of this study is the drying experiments of polymorphism. The crystals of α-L-glutamic acid and β-L-glutamic acid have been prepared by reaction crystallization in this study, respectively. All these reaction products were used for 40°C drying experiments, where weight loss was recorded as a function of time. It could be found that α-L-glutamic acid crystals exhibited a less total drying time. β-L-glutamic acid crystals were easier to retain moisture in their filter cake due to their crystal molecular surface structure. Consequently, α-L-glutamic acid crystals displayed better energy-saving performance in the drying process, reducing α-L-Glu crystals could save 35% of the energy consumption used in drying compared to the produced β-L-Glu crystals. The second part of this study is process design. This study uses the Taguchi Method to look for the optimal parameters to produce α-L-Glu crystals with desired particle size and particle size distribution. The selected parameters include: (1) addition rate of 1M sulfuric acid(aq) (2) reaction temperature, (3) stirring rate, and (4) concentration of L-phenylalanine (L-Phe). According to the response table and figure, the appropriate combination should be selected to produce the desired particle size. Among the four parameters, reaction temperature has the greatest impact on the stability of the system. In addition, the optimal combination that could give the narrowest particle size distribution is 1M H2SO4(aq) addition rate of 1 mL/s, the concentration of L-Phe of 5.20×10-2 M, reaction temperature of 35℃, and stirring rate of 500 rpm. That information will help to further scale up the process.
顯示於類別:	[化學工程與材料工程研究所] 博碩士論文

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