噁唑烷酮稠合?環丙烷之鹵素開環反應研究

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/85887

Title:	噁唑烷酮稠合?環丙烷之鹵素開環反應研究
Authors:	陳韋辰;Chen, Wei-Chen
Contributors:	化學學系
Keywords:	噁唑烷酮稠合?環丙烷;oxazolidinone fused aziridine
Date:	2021-10-28
Issue Date:	2021-12-07 11:38:02 (UTC+8)
Publisher:	國立中央大學
Abstract:	本論文以芳樟醇和香葉醇作為起始物，經果兩步驟反應，得到了有手性的噁唑烷酮稠合?環丙烷，再將這些?環丙烷進行鹵素開環，可以得到單一的鏡像化合物，並且有良好的選擇性和產率。將此策略應用於合成 3-[18F]FV，由於氟的胺基酸 3-[18F]FV可作為腫瘤的快速示?劑，在腫瘤學上是一大突破。因此合成 3-[18F]FV 為本論文致力研究的目標產物。我們使用天然物 L-阿拉伯醣進行多步驟的反應得到烯類化合物，再以此烯類化合物進行多步驟反應生成噁唑烷酮稠合?環丙烷。最後，進行鹵素開環得到單一的鏡像化合物，並且有良好的選擇性，此部分目前只研究到這，我們之後會努力完成它。;In this paper, linalool and geraniol were used as starting materials, and the chiral oxazolidinone fused aziridine was obtained through a two-step reaction. These oxazolidinone fused aziridine are then subjected to halogen ring opening, and a single chiral compound can be obtained with good selectivity and yield. Applying this strategy to the synthesis of 3-[18F]FV, because the amino acid 3-[18F]FV can be used as a rapid tracer of tumors, it is a breakthrough in oncology. Therefore, the synthesis of 3-[18F]FV is the target product of this thesis. We use natural L-arabinose to carry out a multi-step reaction to obtain olefinic compounds, and then use this olefinic compound to carry out a multi-step reaction to generate oxazolidinone fused aziridine . Finally, the halogen ring is opened to obtain a single chiral compound with good selectivity. This part is currently only studied, and we will work hard to complete it.
Appears in Collections:	[Graduate Institute of Chemistry] Electronic Thesis & Dissertation

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