組織工程應用之平面與旋轉兩用式三維生物列印機開發;Development of Planar/Rotary Three-dimensional Bioprinter for Tissue Engineering Applications

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题名:	組織工程應用之平面與旋轉兩用式三維生物列印機開發;Development of Planar/Rotary Three-dimensional Bioprinter for Tissue Engineering Applications
作者:	陳柏任;Chen, Bo-Ren
贡献者:	機械工程學系
关键词:	組織工程;3D 生物列印機;管狀支架;旋轉列印;Tissue engineering;3D Bioprinter;Tubular scaffolds;Additive-lathe
日期:	2022-01-14
上传时间:	2022-07-14 01:20:10 (UTC+8)
出版者:	國立中央大學
摘要:	三維生物列印在近年來已成為一項熱門的生物醫學工程，透過組織工程與積層製造兩項技術的優點，可以客製化製作生物支架，解決難以模擬天然結構或複雜圖形製造之問題。而在積層製造結合旋轉列印技術的發明下，更是為小直徑管狀支架提供多一種的製作方法，在提升製作成功率的同時，也能保持管狀支架中心孔洞的暢通度，成為一種適合管狀支架製作的方式。本研究為使三維生物列印機在保有原先的平面列印下，同時具備旋轉列印的功能，進而開發一台擁有平面與旋轉列印之三維生物列印系統，且在穩定的列印環境下，製作簡單平面支架與空心管狀支架。系統使用乙太網路控制自動化技術(EtherCAT)做為軟硬體的主要通訊方式，其包含設計平面與旋轉可更替式列印平台模組、氣簾封閉式列印環境模組、抗凍液除霜模組、改良之排水模組與紅外線溫度感測模組等。最後使用 C#開發環境，將軟硬體設備整合至一人機控制介面，即可進行操作。本研究透過煙流觀察氣簾生成狀態，再檢測其對列印環境的影響，將結果量化為數據並紀錄。最後使用自行開發之三維生物列印系統，利用氣動擠出式噴頭，分別用於低溫之工作平台與旋轉軸上，嘗試列印殼聚醣平面與管狀支架，以驗證機台之功效。 ;Three-dimensional bioprinting has evolved popular biomedical engineering in recent years. With the advantages of tissue engineering and additive manufacturing, biological scaffolds can be customized by three-dimensional bioprinting, solve the problem that it is difficult to simulate the natural structure or the manufacture of complex graphics. With the invention of layered manufacturing combined with rotary printing technology, it provides more methods for making small-diameter tubular stents. While improving the success rate of production, it can also maintain the smoothness of the central hole of the tubular stent, making it a suitable tube-shaped stent. The way the stent is made. This study aims to develop the three-dimensional bio-printer system with planar and rotation printing funtions. The bio-printer system can manufacture planar scaffolds and hollow tubular scaffolds on the stable circumstance. We use Ethernet Control Automation Technology (EtherCAT) as the main communication method of software and hardware. We have newly designed several modules, for example: planar and rotation replaceable printing platform module, air curtain enclosed printing environment module, antifreeze defrost module, improved drainage module and infrared temperature sensing module, etc. Finally, we develop the user control interface of C# environment to integrate the software and hardware equipment, and the operator can easily perform with simple training. We observe the generation of air curtain through smoke flow, detect the printing circumstance impact of it, and then we quantify the results and record them. At last, we use the pneumatic extrusion nozzle to pinting the chitosan planar and tubular scaffolds on the working platform and rotating shaft of low temperature, to verify the function of the machine.
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