使用演化足跡法識別轉錄因子目標基因; Mootprinting : Identifying transcription factor binding target genes by phylogenetic footprinting

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Title:	使用演化足跡法識別轉錄因子目標基因;Mootprinting : Identifying transcription factor binding target genes by phylogenetic footprinting
Authors:	童志煌;Jyh-Huang Torng
Contributors:	資訊工程研究所
Keywords:	演化足跡法;轉錄因子;phylogenetic footprinting;transcription factor
Date:	2006-06-15
Issue Date:	2009-09-22 11:44:04 (UTC+8)
Publisher:	國立中央大學圖書館
Abstract:	基因表現分析提供許多可能的轉錄因子基因群組，而演化足跡法可用來識別轉錄因子基因。所以我們開發一個結合尋找具有某種特定功能或構造的片段與演化足跡法的系統。在輸入一組具有某種特定功能或構造的片段與基因群組，系統會統計在該片段在人類與老鼠所有基因與基因群上游保守區域的出現情形。系統可以分辨出有可能是某個轉錄因子調控的基因群組或是沒有關係的基因群組。透過比較所有基因與基因群組具有某種特定功能或構造的片段分佈情形，本系統可幫助生物學家識別從基因表現分析得到的群組中，辨識可能是被轉錄因子調控的基因群組。 The analyses of gene expression provide lots of possible transcription factor regulated gene group. It is proven that phylogenetic footprinting method can help to identify transcription factor binding sites. Our work develops a system that combines the motif searching and phylogenetic footprinting. After a motif and gene group is submitted, the system is able to evaluate statistics of motifs appearance in whole genes and a set of genes upstream conserved region between human and mouse. A transcription factor-target gene group was used to test the proposed system. The results present the system can distinguish transcription factor--target gene group from random gene groups. By comparing motif distribution between whole genes and gene group, the proposed system is able to help biologists identify possible transcription factor regulated genes groups form groups of gene expression.
Appears in Collections:	[Graduate Institute of Computer Science and Information Engineering] Electronic Thesis & Dissertation

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