應用脈波傳遞速度於穿戴式裝置血壓量測

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姓名

林品均(Pin-Jun Lin) 查詢紙本館藏

畢業系所

電機工程學系

論文名稱

應用脈波傳遞速度於穿戴式裝置血壓量測

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摘要(中)

非加壓式血壓量測是近年來穿戴式裝置的重要發展技術，在目前提出的技術中，以脈波傳遞速度(Pulse Wave Velocity, PWV)估測血壓之方式為普遍認為最有潛力的技術，利用心電圖(Electrocardiography, ECG)訊號的R波及光體積血容積(Photoplethysmograph, PPG)訊號之波峰間的時間差，計算出PWV並推測血壓，發展出非加壓式血壓量測技術。然而過去發展的研究，因為在參數的規劃與資料的量測上仍然有許多的不確定因素，因此導致以PWV為理論的血壓量測方法，都還在發展的階段。因此，為求數據準確信及可信度，本論文與桃園壢新醫院進行人體試驗 (Institutional Review Board, IRB)合作計畫，由專業心血管醫師篩選患有高血壓及糖尿病病患進行臨床實驗，以左手手腕作為PPG及ECG的量測點，實驗過程透過腳踏車健身器材讓受試者運動5分鐘，誘發收縮壓之提升，同時紀錄該位受試者之年齡、身高體重及病史，數據收集完畢後，利用量測到之ECG及PPG訊號計算脈波傳遞時間(Pulse Transit Time, PTT)，並利用PPG訊號特徵推算受試者之血管彈性係數，以上述之參數進行線性迴歸分析，並與經過FDA認證之生理監控儀器EDAN M50作驗證，結論符合舒張壓及收縮壓與脈波傳遞速度成正比之趨勢，在分析過程中亦得知年齡與PWV之正相關性，實驗結果，估測血壓與實際血壓平均誤差狀態為13%。在研究中發現反射式光學脈搏血氧計會受到光源亮度影響，造成血氧量測上精準度之差異，近而影響不同膚色人種之血壓估測，因此本論文針對光源變數固定完成25-65歲血壓血氧校正曲線，未來將加入自動調光機制，提高使用性及便利性。

摘要(英)

Cuffless blood pressure measurement is an important item for development of wearable technology in recent years. Among current solutions, the pulse wave velocity (PWV)-based method has been regarded as the most potential solution for blood pressure (BP) measurement. The PWV technique measures the pulse-transit time (PTT) between the R wave of ECG and the feature of PPG wave, and uses the PPT to estimate BP. However, current PWV-based methods are still under development, because confounding factors, e.g., signal features, biomarkers, data measurement methods, etc., are still not clear which causes uncertainties in the estimated results. Therefore, to discover a better model for BP estimation using PWV-based approach, we have performed a human experiment in Landseed hospital under the supervision of Institutional Review Board (IRB), Landseed hospital, Taiwan. We have recruited 178 subjects, including normal, hypertension and diabetes patients. All subjects were asked to rest for 5 minutes (Rest State), and then were requested to perform 5 minutes bicycle stepping exercise (Exercise State). The PWV values in the Rest States and Exercise Sates were recorded to incorporate with subjects’ personal information (e.g., age, gender, height, weight) and constructed a linear model using least square regression. The estimated results were compared with EDAN M50 clinical monitoring system. In our study, we have found the PWV presented a high correlation with age and systolic/diastolic blood pressure (SBP/DBP). The estimated error is smaller than 13%. Future developments will focus on the development of algorithm for auto-adjustment of PPG source in order to make our system to adapt the measurements in people with different skin color.

關鍵字(中)

★ 脈波傳遞速度
★ 血壓量測
★ 非加壓式

關鍵字(英)

★ Pulse-wave velocity
★ Blood pressure measurement
★ Cuffless

論文目次

中文摘要i
Abstractii
致謝iii
目錄iv
圖目錄vi
表目錄viii
第一章緒論1
1-1 前言1
1-2 文獻回顧2
1-2-1 加壓式血壓量測2
1-2-2 非加壓式血壓量測4
1-3 市場調查5
1-4 研究動機5
1-5 論文章節架構6
第二章原理介紹7
2-1 心動週期7
2-2 動脈脈搏波8
2-3 動脈血壓9
2-3-1 影響動脈血壓因素9
2-3-2 高血壓10
2-4 心電圖原理(Electrocardiography, ECG)12
2-4-1 心電圖12導程13
2-4-2 心電圖波形14
2-5 光體積血容積(Photoplethysmography, PPG)15
2-6 脈波傳遞速度(Pulse Wave Velocity)17
第三章研究設計與方法18
3-1系統架構18
3-1-1 硬體架構18
3-1-2 訊號處理與分析20
3-1-2-1 訊號處理流程20
3-1-2-2 Pan and Tompkins演算法擷取ECG R-Peak20
3-1-2-3 PPG波峰波谷偵測22
3-1-2-4 脈波傳遞速度(Pulse wave velocity)24
3-1-2-5 血壓線性回歸模型25
3-2 實驗設計25
3-2-1 實驗對象25
3-2-2 實驗設計流程26
第四章結果與討論28
4-1 個人連續估測血壓與實際血壓比較圖28
4-2 不同參數血壓結果比較30
4-3 估測血壓以及實際量測血壓之結果對應31
第五章結論與未來展望37
第六章參考文獻38

參考文獻

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指導教授

李柏磊(Po-Lei Lee)

審核日期

2017-8-23

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