博碩士論文 105821018 詳細資訊




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姓名 董孟融(Meng-Rong Dong)  查詢紙本館藏   畢業系所 生命科學系
論文名稱 環狀核苷酸磷酸二脂酶4B對內毒素刺激小鼠樹突細胞表現NOD1與CXCR4的影響
(Effects of phosphodiesterase 4B in endotoxin-induced NOD1 and CXCR4 expression in mouse bone marrow-derived dendritic cells)
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摘要(中) Pattern recognition receptors (PRRs)在先天免疫中扮演重要的角色。已知在免疫細胞中,活化PRR訊息傳導可誘導許多不同的免疫發炎反應。環狀核苷酸磷酸二脂酶4 (phosphodiesterase 4;PDE4)為免疫細胞內主要分解cAMP的酵素,抑制PDE4活性以提升細胞內cAMP濃度,可減緩多種免疫發炎反應,然而PDE4對於樹突細胞的影響目前仍知之甚少。為此,本研究使用小鼠骨髓細胞分化的樹突細胞(bone marrow-derived dendritic cell;BMDC)進行實驗,並以細菌的成分lipopolysaccharide (LPS)誘導細胞成熟,且在成熟過程中檢測PDE4對NOD1、NOD2與TLR4三種PRRs及趨化激素受器CXCR4 mRNA表現的影響。由定量PCR結果顯示,細胞在LPS刺激4小時後,NOD1與NOD2 mRNA的表現會顯著增加,而TLR4與CXCR4 mRNA則會下降。當以PDE4抑制劑rolipram共同處理細胞時, LPS所誘導的NOD1 mRNA表現會明顯被抑制,然而NOD2、TLR4及CXCR4 mRNA表現量則會上升。在LPS處理BMDC 24-36小時後,四個蛋白質受體的表現皆會降回或低於基礎值。進一步以PDE4基因剔除的BMDC進行實驗,我們發現rolipram對於NOD1 mRNA表現的抑制作用主要是由於抑制了PDE4B及小部分抑制PDE4A所致,而對於CXCR4 mRNA表現的提升則是經由抑制PDE4B所致。至於在LPS對NOD2與TLR4 mRNA的調控中,PDE4的參與相當有限。綜上所述,在LPS誘導BMDC成熟的過程中,PDE4B為主要參與調控NOD1與CXCR4 mRNA表現的PDE4亞型。因此我們認為,PDE4B選擇性抑制劑應可有效降低LPS在樹突細胞內所誘導的NOD1訊息傳導及其發炎反應,同時可增強由CXCR4所引導的移走能力,以提升樹突細胞吞噬病原菌的效率。
摘要(英) Pattern recognition receptors (PRR) are important in innate immunity. Activation of PRRs initiates inflammatory responses in various immune cells, including dendritic cells (DCs). Elevation of cAMP by inhibition of phosphodiesterase 4 (PDE4), enzyme that specifically hydrolyze cAMP, has been shown to suppress a variety of inflammatory response in most inflammatory cells, such as macrophages and T cells, but such information in DCs is less documented. In this study, we investigated the effect of PDE4 in the mRNA expression of the PRRs NOD1, NOD2 and TLR4 and chemokine receptor CXCR4 in bone marrow-derived DCs (BMDCs) during lipopolysaccharide (LPS)-stimulated maturation. Quantitative PCR analysis revealed that the mRNA expression of NOD1 and NOD2 was markedly upregulated, while TLR4 and CXCR4 expression was downregulated at 4h of LPS stimulation. Inhibition of PDE4 with rolipram resulted in a significant reduction of NOD1 but increase in NOD2, TLR4 and CXCR4 mRNA expression. At 24-36h of LPS exposure, the mRNA levels of the four receptors were return to or below the basal levels. Further analysis, using PDE4-/- BMDCs indicated that the effect of rolipram on NOD1 gene expression was mediated by inhibition of PDE4B and, to a lesser extent, PDE4A, while rolipram upregulation of CXCR4 was mediated by inhibition of only PDE4B. The impact of PDE4 on NOD2 gene expression was limited, when LPS is present. Taken together, these finding demonstrate that PDE4, mainly the PDE4B isoform, is involved in the expression of NOD1 and CXCR4 in BMDCs during LPS-induced maturation. This suggests that PDE4B-selected inhibitors may inhibit LPS-elicited NOD1 signaling and its inflammatory responses as well as promote CXCR4-directed DC migration for pathogen capturing.
關鍵字(中) ★ 環狀核苷酸磷酸二脂酶
★ 樹突細胞
★ 環腺苷酸
★ 脂多醣
關鍵字(英) ★ phosphodiesterase,PDE
★ PDE4
★ cAMP
★ dendritic cell
★ LPS
★ NOD1
★ NOD2
★ TLR4
★ CXCR4
論文目次 中文摘要 ……………………………………………………………… i
英文摘要 ……………………………………………………………… ii
誌謝 ……………………………………………………………… iv
目錄 ……………………………………………………………… v
圖目錄 ……………………………………………………………… viii
縮寫檢索表 ……………………………………………………………… ix
一、 緒論………………………………………………………… 1
1-1 樹突細胞(Dendritic cell)…………………………………... 1
1-2 樹突細胞的成熟作用……………………………………… 1
1-3 樹突細胞的種類與特性…………………………………… 2
1-4 樹突細胞與自體免疫疾病………………………………… 3
1-5 Pattern recognition receptor (PRR)………………………… 3
1-5-1 Toll-like receptor (TLR)…………………………………… 4
1-5-2 Toll-like receptor 4…………………………………………. 4
1-5-3 Nucleotide-binding oligomerization domain-like receptor (NOD-like receptor;NLR)……………………………......
5
1-5-4 NOD1與NOD2…………………………………………… 6
1-6-1 腺嘌呤環狀核苷酸( cyclic adenosine monophosphate;cAMP)訊息傳導……………………………………………
7
1-6-2 cAMP與免疫發炎反應………………………………….... 8
1-7 環狀核苷酸磷酸二脂酶(Cyclic nucleotide Phosphodiesterase;PDE) …………………………………
8
1-7-1 PDE4……………………………………………………….. 10
1-7-2 PDE4抑制劑與免疫功能調節……………………………. 11
1-8 C-X-C chemokine receptor type 4 (CXCR-4)……………... 12
二、 研究動機與目的…………………………………………… 14
三、 實驗材料與方法…………………………………………… 15
3-1 實驗材料…………………………………………………… 15
3-1-1 實驗小鼠…………………………………………………… 15
3-1-2 實驗用藥品………………………………………………… 15
3-1-2-1 細胞培養相關溶液………………………………………… 15
3-1-2-2 處理細胞之小分子藥劑…………………………………… 16
3-1-2-3 萃取RNA與qPCR相關試劑……………………………. 16
3-2 實驗方法…………………………………………………… 16
3-2-1 配製C10培養液…………………………………………... 16
3-2-2 分離小鼠骨髓細胞………………………………………… 16
3-2-3 小鼠骨髓細胞分化為未成熟樹突細胞…………………… 17
3-2-4 未成熟樹突細胞分化為成熟樹突細胞…………………… 17
3-2-5 萃取樹突細胞內RNA…………………………………….. 18
3-2-6 反轉錄作用………………………………………………… 18
3-2-7 cDNA cleaning…………………………………………….. 18
3-2-8 定量聚合酵素連鎖反應(Quantitative PCR)……….... 19
四、 實驗結果…………………………………………………… 20
4-1 NOD1、NOD2、TLR4及CXCR4在未成熟樹突細胞中的表現………………………………………………………
20
4-2 PDE4抑制劑可降低樹突細胞內LPS誘導NOD1 mRNA的表現………………………………………………………
20
4-3 剔除PDE4A與PDE4B可抑制樹突細胞內LPS誘導NOD1 mRNA的表現………………………………….......
21
4-4 PDE4抑制劑對樹突細胞內LPS誘導NOD2 mRNA表現的影響……………………………………………………
22
4-5 在LPS刺激樹突細胞成熟過程中抑制PDE4B可誘導NOD2基因的表現………………………………………....
23
4-6 LPS與PDE4對樹突細胞內TLR4基因表現的調控…… 23
4-7 在樹突細胞中剔除PDE4B可減緩LPS對TLR4基因表現的抑制作用………………………………………………
24
4-8 在LPS刺激樹突細胞成熟過程中PDE4對CXCR4 mRNA表現的影響………………………………………...
25
4-9 在LPS活化的樹突細胞中剔除PDE4B可增加CXCR4 mRNA的表現……………………………………………...
25
五、 討論………………………………………………………… 27
六、 圖與圖解…………………………………………………… 32
參考文獻 ……………………………………………………………… 43
參考文獻 Aandahl, E.M., W.J. Moretto, P.A. Haslett, T. Vang, T. Bryn, K. Tasken, and D.F. Nixon. 2002. Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I. Journal of immunology (Baltimore, Md. : 1950) 169:802-808.
Ait Yahia, S., I. Azzaoui, L. Everaere, H. Vorng, C. Chenivesse, P. Marquillies, C. Duez, M. Delacre, T. Grandjean, J. Balsamelli, M. Fanton d′Andon, Y. Fan, C. Ple, C. Werts, I.G. Boneca, B. Wallaert, M. Chamaillard, and A. Tsicopoulos. 2014. CCL17 production by dendritic cells is required for NOD1-mediated exacerbation of allergic asthma. American journal of respiratory and critical care medicine 189:899-908.
Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nature reviews. Immunology 4:499-511.
Asirvatham, A.L., S.G. Galligan, R.V. Schillace, M.P. Davey, V. Vasta, J.A. Beavo, and D.W. Carr. 2004. A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines. J Immunol 173:4806-4814.
Asselin-Paturel, C., A. Boonstra, M. Dalod, I. Durand, N. Yessaad, C. Dezutter-Dambuyant, A. Vicari, A. O′Garra, C. Biron, F. Brière, and G. Trinchieri. 2001. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nature Immunology 2:1144.
Baillie, G.S., S.J. MacKenzie, I. McPhee, and M.D. Houslay. 2000. Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases. British journal of pharmacology 131:811-819.
Barber, R.C., L.Y. Chang, B.D. Arnoldo, G.F. Purdue, J.L. Hunt, J.W. Horton, and C.C. Aragaki. 2006. Innate immunity SNPs are associated with risk for severe sepsis after burn injury. Clinical medicine & research 4:250-255.
Beard, M.B., A.E. Olsen, R.E. Jones, S. Erdogan, M.D. Houslay, and G.B. Bolger. 2000. UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions. The Journal of biological chemistry 275:10349-10358.
Björck, P., A. Beilhack, E.I. Herman, R.S. Negrin, and E.G. Engleman. 2008. Plasmacytoid Dendritic Cells Take Up Opsonized Antigen Leading to CD4+ and CD8+ T Cell Activation In Vivo. The Journal of Immunology 181:3811-3817.
Busillo, J.M., and J.L. Benovic. 2007. Regulation of CXCR4 signaling. Biochimica et biophysica acta 1768:952-963.
Caruso, R., N. Warner, N. Inohara, and G. Nunez. 2014. NOD1 and NOD2: signaling, host defense, and inflammatory disease. Immunity 41:898-908.
Chamaillard, M., M. Hashimoto, Y. Horie, J. Masumoto, S. Qiu, L. Saab, Y. Ogura, A. Kawasaki, K. Fukase, S. Kusumoto, M.A. Valvano, S.J. Foster, T.W. Mak, G. Nunez, and N. Inohara. 2003. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol 4:702-707.
Chan, V.S., Y.J. Nie, N. Shen, S. Yan, M.Y. Mok, and C.S. Lau. 2012. Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus. Autoimmunity reviews 11:890-897.
Chatterjee, S., B. Behnam Azad, and S. Nimmagadda. 2014. The intricate role of CXCR4 in cancer. Advances in cancer research 124:31-82.
Chen, G., M.H. Shaw, Y.-G. Kim, and G. Nuñez. 2009. NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease. Annual Review of Pathology: Mechanisms of Disease 4:365-398.
Colonna, M., G. Trinchieri, and Y.-J. Liu. 2004. Plasmacytoid dendritic cells in immunity. Nature Immunology 5:1219.
Conti, M., and J. Beavo. 2007. Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling. Annual Review of Biochemistry 76:481-511.
Correa, R.G., S. Milutinovic, and J.C. Reed. 2012. Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases. Bioscience reports 32:597-608.
Czeloth, N., A. Schippers, N. Wagner, W. Müller, B. Küster, G. Bernhardt, and R. Förster. 2007. Sphingosine-1 Phosphate Signaling Regulates Positioning of Dendritic Cells within the Spleen. The Journal of Immunology 179:5855-5863.
De Creus, A., M. Abe, A.H. Lau, H. Hackstein, G. Raimondi, and A.W. Thomson. 2005. Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin. Journal of immunology (Baltimore, Md. : 1950) 174:2037-2045.
Degraaf, A.J., Z. Zaslona, E. Bourdonnay, and M. Peters-Golden. 2014. Prostaglandin E2 reduces Toll-like receptor 4 expression in alveolar macrophages by inhibition of translation. American journal of respiratory cell and molecular biology 51:242-250.
Dotan, I., L. Werner, S. Vigodman, S. Weiss, E. Brazowski, N. Maharshak, O. Chen, H. Tulchinsky, Z. Halpern, and H. Guzner-Gur. 2010. CXCL12 is a constitutive and inflammatory chemokine in the intestinal immune system. Inflammatory bowel diseases 16:583-592.
Essayan, D.M., A. Kagey-Sobotka, L.M. Lichtenstein, and S.K. Huang. 1997a. Differential regulation of human antigen-specific Th1 and Th2 lymphocyte responses by isozyme selective cyclic nucleotide phosphodiesterase inhibitors. The Journal of pharmacology and experimental therapeutics 282:505-512.
Essayan, D.M., A. Kagey-Sobotka, L.M. Lichtenstein, and S.K. Huang. 1997b. Regulation of interleukin-13 by type 4 cyclic nucleotide phosphodiesterase (PDE) inhibitors in allergen-specific human T lymphocyte clones. Biochemical pharmacology 53:1055-1060.
Gallo, P., and S. Gallucci. 2013. The Dendritic Cell Response to Classic, Emerging, and Homeostatic Danger Signals. Implications for Autoimmunity. Frontiers in immunology 4:
Gay, N.J., M.F. Symmons, M. Gangloff, and C.E. Bryant. 2014. Assembly and localization of Toll-like receptor signalling complexes. Nature reviews. Immunology 14:546-558.
Gilliet, M., A. Boonstra, C. Paturel, S. Antonenko, X.-L. Xu, G. Trinchieri, A. O′Garra, and Y.-J. Liu. 2002. The Development of Murine Plasmacytoid Dendritic Cell Precursors Is Differentially Regulated by FLT3-ligand and Granulocyte/Macrophage Colony-Stimulating Factor. The Journal of Experimental Medicine 195:953-958.
Goichberg, P., A. Kalinkovich, N. Borodovsky, M. Tesio, I. Petit, A. Nagler, I. Hardan, and T. Lapidot. 2006. cAMP-induced PKCzeta activation increases functional CXCR4 expression on human CD34+ hematopoietic progenitors. Blood 107:870-879.
Gross-Langenhoff, M., K. Hofbauer, J. Weber, A. Schultz, and J.E. Schultz. 2006. cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11. The Journal of biological chemistry 281:2841-2846.
Gutierrez, O., C. Pipaon, N. Inohara, A. Fontalba, Y. Ogura, F. Prosper, G. Nunez, and J.L. Fernandez-Luna. 2002. Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation. The Journal of biological chemistry 277:41701-41705.
Guzzo, C., A. Ayer, S. Basta, B.W. Banfield, and K. Gee. 2012. IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes. Journal of immunology (Baltimore, Md. : 1950) 188:864-873.
Handa, N., E. Mizohata, S. Kishishita, M. Toyama, S. Morita, T. Uchikubo-Kamo, R. Akasaka, K. Omori, J. Kotera, T. Terada, M. Shirouzu, and S. Yokoyama. 2008. Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP. The Journal of biological chemistry 283:19657-19664.
Hansen, R.T., 3rd, M. Conti, and H.T. Zhang. 2014. Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior. Psychopharmacology (Berl) 231:2941-2954.
Harvath, L., J.D. Robbins, A.A. Russell, and K.B. Seamon. 1991. cAMP and human neutrophil chemotaxis. Elevation of cAMP differentially affects chemotactic responsiveness. Journal of immunology (Baltimore, Md. : 1950) 146:224-232.
Hatzelmann, A., and C. Schudt. 2001. Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. The Journal of pharmacology and experimental therapeutics 297:267-279.
Heystek, H.C., A.C. Thierry, P. Soulard, and C. Moulon. 2003. Phosphodiesterase 4 inhibitors reduce human dendritic cell inflammatory cytokine production and Th1-polarizing capacity. International immunology 15:827-835.
Hoffmann, R., G.S. Baillie, S.J. MacKenzie, S.J. Yarwood, and M.D. Houslay. 1999. The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579. The EMBO journal 18:893-903.
Hubert, F.-X., C. Voisine, C. Louvet, J.-M. Heslan, A. Ouabed, M. Heslan, and R. Josien. 2006. Differential Pattern Recognition Receptor Expression but Stereotyped Responsiveness in Rat Spleen Dendritic Cell Subsets. The Journal of Immunology 177:1007-1016.
Hysi, P., M. Kabesch, M.F. Moffatt, M. Schedel, D. Carr, Y. Zhang, B. Boardman, E. von Mutius, S.K. Weiland, W. Leupold, C. Fritzsch, N. Klopp, A.W. Musk, A. James, G. Nunez, N. Inohara, and W.O. Cookson. 2005. NOD1 variation, immunoglobulin E and asthma. Human molecular genetics 14:935-941.
Irving, A.T., H. Mimuro, T.A. Kufer, C. Lo, R. Wheeler, L.J. Turner, B.J. Thomas, C. Malosse, M.P. Gantier, L.N. Casillas, B.J. Votta, J. Bertin, I.G. Boneca, C. Sasakawa, D.J. Philpott, R.L. Ferrero, and M. Kaparakis-Liaskos. 2014. The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling. Cell host & microbe 15:623-635.
Jacob, C., C. Szilagyi, J.M. Allen, C. Bertrand, and V. Lagente. 2004. Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism. British journal of pharmacology 143:257-268.
Jager, R., C. Russwurm, F. Schwede, H.G. Genieser, D. Koesling, and M. Russwurm. 2012. Activation of PDE10 and PDE11 phosphodiesterases. The Journal of biological chemistry 287:1210-1219.
Jeon, D.I., S.R. Park, M.Y. Ahn, S.G. Ahn, J.H. Park, and J.H. Yoon. 2012. NOD1 and NOD2 stimulation triggers innate immune responses of human periodontal ligament cells. International journal of molecular medicine 29:699-703.
Jin, S.L., and M. Conti. 2002. Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses. Proceedings of the National Academy of Sciences of the United States of America 99:7628-7633.
Jin, S.L., S.L. Ding, and S.C. Lin. 2012. Phosphodiesterase 4 and its inhibitors in inflammatory diseases. Chang Gung medical journal 35:197-210.
Jin, S.L., S. Goya, S. Nakae, D. Wang, M. Bruss, C. Hou, D. Umetsu, and M. Conti. 2010. Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma. The Journal of allergy and clinical immunology 126:1252-1259.e1212.
Jin, S.L., L. Lan, M. Zoudilova, and M. Conti. 2005. Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages. Journal of immunology (Baltimore, Md. : 1950) 175:1523-1531.
Jin, S.L., F.J. Richard, W.P. Kuo, A.J. D′Ercole, and M. Conti. 1999. Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 96:11998-12003.
Kadowaki, N., S. Antonenko, J.Y.-N. Lau, and Y.-J. Liu. 2000. Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity. The Journal of Experimental Medicine 192:219-226.
Kambayashi, T., R.P. Wallin, and H.G. Ljunggren. 2001. cAMP-elevating agents suppress dendritic cell function. Journal of leukocyte biology 70:903-910.
Kamenetsky, M., S. Middelhaufe, E.M. Bank, L.R. Levin, J. Buck, and C. Steegborn. 2006. Molecular details of cAMP generation in mammalian cells: a tale of two systems. Journal of molecular biology 362:623-639.
Kawai, T., and S. Akira. 2011. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34:637-650.
Kim, D., Y.G. Kim, S.U. Seo, D.J. Kim, N. Kamada, D. Prescott, M. Chamaillard, D.J. Philpott, P. Rosenstiel, N. Inohara, and G. Nunez. 2016. Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin. Nature medicine 22:524-530.
Kim, H.K., J.E. Kim, J. Chung, K.S. Han, and H.I. Cho. 2007a. Surface expression of neutrophil CXCR4 is down-modulated by bacterial endotoxin. International journal of hematology 85:390-396.
Kim, K.W., M.L. Cho, H.R. Kim, J.H. Ju, M.K. Park, H.J. Oh, J.S. Kim, S.H. Park, S.H. Lee, and H.Y. Kim. 2007b. Up-regulation of stromal cell-derived factor 1 (CXCL12) production in rheumatoid synovial fibroblasts through interactions with T lymphocytes: role of interleukin-17 and CD40L-CD40 interaction. Arthritis and rheumatism 56:1076-1086.
Klarquist, J., Z. Zhou, N. Shen, and E.M. Janssen. 2016. Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools. 12 pp.
Lai, C.-R., H.-C. Lo, Y.-L. Chen, J.-X. Yang, S.-L. Ding, H.-H. Hsu, M. Conti, C.-P. Wu, and S. Catherine Jin. 2015. Phosphodiesterase 4B is essential for lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages. Journal of Medical Sciences 35:111-119.
Lande, R., J. Gregorio, V. Facchinetti, B. Chatterjee, Y.-H. Wang, B. Homey, W. Cao, Y.-H. Wang, B. Su, F.O. Nestle, T. Zal, I. Mellman, J.-M. Schröder, Y.-J. Liu, and M. Gilliet. 2007. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449:564.
Lehnart, S.E., X.H. Wehrens, S. Reiken, S. Warrier, A.E. Belevych, R.D. Harvey, W. Richter, S.L. Jin, M. Conti, and A.R. Marks. 2005. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell 123:25-35.
Li, L., C. Yee, and J.A. Beavo. 1999. CD3- and CD28-dependent induction of PDE7 required for T cell activation. Science (New York, N.Y.) 283:848-851.
Liu, W.T., Y.Y. Jing, F. Yan, Z.P. Han, F.B. Lai, J.X. Zeng, G.F. Yu, Q.M. Fan, R. Li, Q.D. Zhao, M.C. Wu, and L.X. Wei. 2017. LPS-induced CXCR4-dependent migratory properties and a mesenchymal-like phenotype of colorectal cancer cells. Cell adhesion & migration 11:13-23.
Lowes, M.A., A.M. Bowcock, and J.G. Krueger. 2007. Pathogenesis and therapy of psoriasis. Nature 445:866.
Ma, Q., D. Jones, P.R. Borghesani, R.A. Segal, T. Nagasawa, T. Kishimoto, R.T. Bronson, and T.A. Springer. 1998. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 95:9448-9453.
Marriott, I., D.M. Rati, S.H. McCall, and S.L. Tranguch. 2005. Induction of Nod1 and Nod2 intracellular pattern recognition receptors in murine osteoblasts following bacterial challenge. Infection and immunity 73:2967-2973.
Martinez, S.E., A.Y. Wu, N.A. Glavas, X.B. Tang, S. Turley, W.G. Hol, and J.A. Beavo. 2002. The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. Proceedings of the National Academy of Sciences of the United States of America 99:13260-13265.
Matthiesen, K., and J. Nielsen. 2009. Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity. The Biochemical journal 423:401-409.
Maurice, D.H., H. Ke, F. Ahmad, Y. Wang, J. Chung, and V.C. Manganiello. 2014. Advances in targeting cyclic nucleotide phosphodiesterases. Nature reviews. Drug discovery 13:290-314.
Merad, M., P. Sathe, J. Helft, J. Miller, and A. Mortha. 2013. The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting. Annual Review of Immunology 31:563-604.
Miceli-Richard, C., S. Lesage, M. Rybojad, A.M. Prieur, S. Manouvrier-Hanu, R. Hafner, M. Chamaillard, H. Zouali, G. Thomas, and J.P. Hugot. 2001. CARD15 mutations in Blau syndrome. Nature genetics 29:19-20.
Motta, V., F. Soares, T. Sun, and D.J. Philpott. 2015. NOD-like receptors: versatile cytosolic sentinels. Physiol Rev 95:149-178.
Muradov, H., K.K. Boyd, and N.O. Artemyev. 2004. Structural determinants of the PDE6 GAF A domain for binding the inhibitory gamma-subunit and noncatalytic cGMP. Vision research 44:2437-2444.
Nakamura, N., J.R. Lill, Q. Phung, Z. Jiang, C. Bakalarski, A. de Maziere, J. Klumperman, M. Schlatter, L. Delamarre, and I. Mellman. 2014. Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nature 509:240-244.
Nambu, M., M. Morita, H. Watanabe, Y. Uenoyama, K.M. Kim, M. Tanaka, Y. Iwai, H. Kimata, M. Mayumi, and H. Mikawa. 1989. Regulation of Fc gamma receptor expression and phagocytosis of a human monoblast cell line U937. Participation of cAMP and protein kinase C in the effects of IFN-gamma and phorbol ester. Journal of immunology (Baltimore, Md. : 1950) 143:4158-4165.
Nestle, F.O., D.H. Kaplan, and J. Barker. 2009. Psoriasis. New Engl J Med 361:496-509.
Nhu, Q.M., N. Cuesta, and S.N. Vogel. 2006. Transcriptional regulation of lipopolysaccharide (LPS)-induced Toll-like receptor (TLR) expression in murine macrophages: role of interferon regulatory factors 1 (IRF-1) and 2 (IRF-2). Journal of endotoxin research 12:285-295.
Omori, K., and J. Kotera. 2007. Overview of PDEs and their regulation. Circulation research 100:309-327.
Pandit, J., M.D. Forman, K.F. Fennell, K.S. Dillman, and F.S. Menniti. 2009. Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. Proceedings of the National Academy of Sciences of the United States of America 106:18225-18230.
Park, S.Y., S.W. Lee, S.H. Baek, C.W. Lee, W.S. Lee, B.Y. Rhim, K.W. Hong, and C.D. Kim. 2013. Suppression of PU.1-linked TLR4 expression by cilostazol with decrease of cytokine production in macrophages from patients with rheumatoid arthritis. British journal of pharmacology 168:1401-1411.
Persson, C.M., and B.J. Chambers. 2010. Plasmacytoid dendritic cell-induced migration and activation of NK cells in vivo. European Journal of Immunology 40:2155-2164.
Raker, V.K., C. Becker, and K. Steinbrink. 2016. The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases. Frontiers in immunology 7:123.
Randolph, G.J., V. Angeli, and M.A. Swartz. 2005. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nature reviews. Immunology 5:617-628.
Roake, J.A., A.S. Rao, P.J. Morris, C.P. Larsen, D.F. Hankins, and J.M. Austyn. 1995. Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. The Journal of Experimental Medicine 181:2237-2247.
Robichaud, A., P.B. Stamatiou, S.L. Jin, N. Lachance, D. MacDonald, F. Laliberte, S. Liu, Z. Huang, M. Conti, and C.C. Chan. 2002. Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. J Clin Invest 110:1045-1052.
Roger, T., I. Miconnet, A.L. Schiesser, H. Kai, K. Miyake, and T. Calandra. 2005. Critical role for Ets, AP-1 and GATA-like transcription factors in regulating mouse Toll-like receptor 4 (Tlr4) gene expression. The Biochemical journal 387:355-365.
Rosenstiel, P., M. Fantini, K. Brautigam, T. Kuhbacher, G.H. Waetzig, D. Seegert, and S. Schreiber. 2003. TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology 124:1001-1009.
Rybalkin, S.D., I.G. Rybalkina, R. Feil, F. Hofmann, and J.A. Beavo. 2002. Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells. The Journal of biological chemistry 277:3310-3317.
Rybalkin, S.D., I.G. Rybalkina, M. Shimizu-Albergine, X.B. Tang, and J.A. Beavo. 2003. PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. The EMBO journal 22:469-478.
Saccani, A., S. Saccani, S. Orlando, M. Sironi, S. Bernasconi, P. Ghezzi, A. Mantovani, and A. Sica. 2000. Redox regulation of chemokine receptor expression. Proceedings of the National Academy of Sciences of the United States of America 97:2761-2766.
Sallusto, F., P. Schaerli, P. Loetscher, C. Schaniel, D. Lenig, C.R. Mackay, S. Qin, and A. Lanzavecchia. 1998. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. European Journal of Immunology 28:2760-2769.
Saxena, V., J.K. Ondr, A.F. Magnusen, D.H. Munn, and J.D. Katz. 2007. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. Journal of immunology (Baltimore, Md. : 1950) 179:5041-5053.
Serezani, C.H., M.N. Ballinger, D.M. Aronoff, and M. Peters-Golden. 2008. Cyclic AMP: master regulator of innate immune cell function. American journal of respiratory cell and molecular biology 39:127-132.
Sharma, R.K., S.B. Das, A. Lakshmikuttyamma, P. Selvakumar, and A. Shrivastav. 2006. Regulation of calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1): review. International journal of molecular medicine 18:95-105.
Spörri, R., and C. Reis e Sousa. 2005. Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. Nature Immunology 6:163.
Steinman, R.M., and Z.A. Cohn. 1973. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 137:1142-1162.
Takahashi, Y., K. Isuzugawa, Y. Murase, M. Imai, S. Yamamoto, M. Iizuka, S. Akira, G.M. Bahr, E. Momotani, M. Hori, H. Ozaki, and K. Imakawa. 2006. Up-regulation of NOD1 and NOD2 through TLR4 and TNF-alpha in LPS-treated murine macrophages. The Journal of veterinary medical science 68:471-478.
Takeda, K., T. Kaisho, and S. Akira. 2003. Toll-like receptors. Annu Rev Immunol 21:335-376.
Tal, G., A. Mandelberg, I. Dalal, K. Cesar, E. Somekh, A. Tal, A. Oron, S. Itskovich, A. Ballin, S. Houri, A. Beigelman, O. Lider, G. Rechavi, and N. Amariglio. 2004. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. The Journal of infectious diseases 189:2057-2063.
Tal, O., H.Y. Lim, I. Gurevich, I. Milo, Z. Shipony, L.G. Ng, V. Angeli, and G. Shakhar. 2011. DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling. The Journal of Experimental Medicine
Teicher, B.A., and S.P. Fricker. 2010. CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 16:2927-2931.
Thay, B., A. Damm, T.A. Kufer, S.N. Wai, and J. Oscarsson. 2014. Aggregatibacter actinomycetemcomitans outer membrane vesicles are internalized in human host cells and trigger NOD1- and NOD2-dependent NF-kappaB activation. Infection and immunity 82:4034-4046.
Ting, J.P., R.C. Lovering, E.S. Alnemri, J. Bertin, J.M. Boss, B.K. Davis, R.A. Flavell, S.E. Girardin, A. Godzik, J.A. Harton, H.M. Hoffman, J.P. Hugot, N. Inohara, A. Mackenzie, L.J. Maltais, G. Nunez, Y. Ogura, L.A. Otten, D. Philpott, J.C. Reed, W. Reith, S. Schreiber, V. Steimle, and P.A. Ward. 2008. The NLR gene family: a standard nomenclature. Immunity 28:285-287.
Torphy, T.J. 1998. Phosphodiesterase isozymes: molecular targets for novel antiasthma agents. American journal of respiratory and critical care medicine 157:351-370.
van de Laar, L., P.J. Coffer, and A.M. Woltman. 2012. Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy. Blood 119:3383-3393.
van Heel, D.A., S. Ghosh, M. Butler, K.A. Hunt, A.M. Lundberg, T. Ahmad, D.P. McGovern, C. Onnie, K. Negoro, S. Goldthorpe, B.M. Foxwell, C.G. Mathew, A. Forbes, D.P. Jewell, and R.J. Playford. 2005. Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn′s disease. Lancet (London, England) 365:1794-1796.
Vaure, C., and Y. Liu. 2014. A comparative review of toll-like receptor 4 expression and functionality in different animal species. Frontiers in immunology 5:316.
Visintin, A., A. Mazzoni, J.H. Spitzer, D.H. Wyllie, S.K. Dower, and D.M. Segal. 2001. Regulation of Toll-like receptors in human monocytes and dendritic cells. Journal of immunology (Baltimore, Md. : 1950) 166:249-255.
Wall, E.A., J.R. Zavzavadjian, M.S. Chang, B. Randhawa, X. Zhu, R.C. Hsueh, J. Liu, A. Driver, X.R. Bao, P.C. Sternweis, M.I. Simon, and I.D. Fraser. 2009. Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105. Science signaling 2:ra28.
Wan, X., C. Cheng, Z. Lin, R. Jiang, W. Zhao, X. Yan, J. Tang, K. Yao, B. Sun, and Y. Chen. 2015. The attenuated hepatocellular carcinoma-specific Listeria vaccine Lmdd-MPFG prevents tumor occurrence through immune regulation of dendritic cells. Oncotarget 6:8822-8838.
West, A.P., A.A. Koblansky, and S. Ghosh. 2006. Recognition and Signaling by Toll-Like Receptors. Annual Review of Cell and Developmental Biology 22:409-437.
Wohn, C., J.L. Ober-Blöbaum, S. Haak, S. Pantelyushin, C. Cheong, S.P. Zahner, S. Onderwater, M. Kant, H. Weighardt, B. Holzmann, B. Reizis, B. Becher, E.P. Prens, and B.E. Clausen. 2013. Langerinneg conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice. Proceedings of the National Academy of Sciences 110:10723-10728.
Xing, Q., P. de Vos, M.M. Faas, Q. Ye, and Y. Ren. 2011. LPS promotes pre-osteoclast activity by up-regulating CXCR4 via TLR-4. Journal of dental research 90:157-162.
Yang, J.X., K.C. Hsieh, Y.L. Chen, C.K. Lee, M. Conti, T.H. Chuang, C.P. Wu, and S.C. Jin. 2017. Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages. Scientific reports 7:46165.
Yang, J.X., T.C. Hsiung, F.C. Weng, S.L. Ding, C.P. Wu, M. Conti, T.H. Chuang, and S.L. Catherine Jin. 2018. Synergistic effect of phosphodiesterase 4 inhibitor and serum on migration of endotoxin-stimulated macrophages. Innate immunity 24:501-512.
Zhang, H.T., Y. Huang, S.L. Jin, S.A. Frith, N. Suvarna, M. Conti, and J.M. O′Donnell. 2002. Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 27:587-595.
指導教授 金秀蓮(Shiow-Lian Catherine Jin) 審核日期 2019-1-23
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