Early Detection of Mouse Liver Fibrosis Using Segmentation of MR Images with Confusion Component Removing and Morphology

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姓名

邱繼賢(Chi-Hsien Chiu) 查詢紙本館藏

畢業系所

數學系

論文名稱

(Early Detection of Mouse Liver Fibrosis Using Segmentation of MR Images with Confusion Component Removing and Morphology)

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摘要(中)

慢性肝病常會進行到不可逆的肝硬化階段，但是在肝纖維化的早期，其病勢是可逆的。
雖然侵入式診斷是目前評斷肝纖維化的黃金標準，除了成本較為高昂且會造成病人的
痛苦且帶有些微機率的後遺症。所以我們希望能建立一套簡單但可靠的非侵入式評分
方法，並期望能判別患者肝纖維化的程度。主要影像是使用小鼠的MR 影像，利用
MR 影像的T1 和T1ct (Primovist) 各自的成像差異加上K-means 法把肝影像分割出來。我們架構的模型主要使用Support vector machine (SVM) 去進行分類。透過觀察,我們使用simple connected domain 的機率當作其中的一個特徵，並用孔隙率當作第二個特徵。由於SVM 本身是Binary 分類器，所以我們選用One-Against-One 策略，使用多個Binary 分類器去達到我們想要的分類效果。由於資料組數較少，因此我們選用K-Fold 交錯驗證法來增強結果的可信度。單獨使用孔隙率當作特徵所得到的模型準確率大約有80%，根據ROC 曲線分析，可以得出其AUROC 分數大約為0.7 ∼ 0.8 之間，但如果加上simple connected domain 作為第二特徵，訓練出來的模型準確率可達 90%，AUROC 分數可達將近0.9，代表其判斷結果是可信的。

摘要(英)

Chronic liver disease often progresses to the irreversible stage of cirrhosis, but in the early
stage of liver fibrosis, its disease is reversible. Although the invasive diagnosis is currently
the gold standard for judging liver fibrosis, in addition to the high cost and the painful
sequelae of the patient with some micro-probability. Therefore, we hope to establish a
simple but reliable non-invasive scoring method and hope to determine the degree of liver
fibrosis in patients. The main image is the MR image of the mouse. The liver image is
segmented using the respective imaging differences of T1 and T1ct (Primovist) of MRI
plus the K-means method. The model of our architecture mainly uses a support vector
machine (SVM) to classify. Through our observation, we use the degree of the simple
connected domain as one of the features, and the porosity as the second feature. Since
SVM is a binary classifier, we choose the one-against-one mode and use multiple binary
classifiers to achieve the classification effect we want. Due to the small number of data
sets, we choose K-Fold cross-validation to enhance the credibility of the results. The
accuracy of the model obtained by using porosity alone as a feature is only about 80%.
According to the ROC curve analysis, it can be concluded that its AUROC score is about
0.7∼0.8, but if the simple connected domain is added as the second feature, the accuracy
of the trained model can reach 90%, and the AUROC score can reach close to 0.9, which means that the judgment result is credible.

關鍵字(中)

★ 肝纖維化

關鍵字(英)

★ Liver Fibrosis

論文目次

Tables . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
Figures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . x
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
2 Segmented morphology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
2.1 Images segmentation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
2.2 Methodology of Morphology . . . . . . . . . . . . . . . . . . . . . . . . . . 5
2.2.1 Basic Morphological Operators . . . . . . . . . . . . . . . . . . . . 5
3 Proposed diagnosis technique . . . . . . . . . . . . . . . . . . . . . . . . . 10
3.1 Feature extraction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
3.1.1 Feature 1 : Simple connected domain . . . . . . . . . . . . . . . . 10
3.1.2 Feature 2 : Porosity . . . . . . . . . . . . . . . . . . . . . . . . . . 12
3.2 Cross validation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
3.3 Classification Method : Support Vector Machine (SVM) . . . . . . . . . . 16
3.3.1 One-Against-One (OAO) . . . . . . . . . . . . . . . . . . . . . . . . 17
4 Diagnosis results and discussions . . . . . . . . . . . . . . . . . . . . . . . . 19
4.1 Data information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
4.2 Diagnosis processed result . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
4.3 Feature 1 & Feature 2 results . . . . . . . . . . . . . . . . . . . . . . . . . 21
4.3.1 Feature 1 : Simple connected domain . . . . . . . . . . . . . . . . . 21
4.3.2 Feature 2 : Porosity . . . . . . . . . . . . . . . . . . . . . . . . . 21
4.4 Statistical Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22
4.4.1 ROC Curve & AUROC Analysis . . . . . . . . . . . . . . . . . . . 26
5 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28
Bibliography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29

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指導教授

黃楓南(Feng-Nan Hwang)

審核日期

2020-8-19

推文