結合漫反射光譜及蒙地卡羅分析建立瘀傷時間模型

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姓名

王翊蓁(Yi-Zhen Wang) 查詢紙本館藏

畢業系所

光電科學與工程學系

論文名稱

結合漫反射光譜及蒙地卡羅分析建立瘀傷時間模型

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至系統瀏覽論文 (2029-8-12以後開放)

摘要(中)

光學檢測技術因為具有不破壞生物體本身的優點，普遍被應用在生醫研究上，近年來隨著健康意識逐漸抬頭，非侵入式技術漸漸應用於人體的生理指數分析上。
　漫反射光譜(DRS, diffuse reflectance spectroscopy)是光學檢測技術在人體上最常被使用的技術，藉由光譜表現、反射率與濃度的分析可獲得多項無法用肉眼觀察到的皮下組織數據，例如帶氧血紅素、不帶氧血紅素、膽紅素等等數值，這些數據有助於了解受試者當下的瘀傷程度，以及瘀傷的癒合及形成時間。
　本研究以漫反射光譜量測系統搭配主成分分析法，透過類神經網路獲得皮下組織含量變化，進而進行生理數值分析。透過收集有瘀傷的受試者，將受傷區域採集漫反射光譜及二維影像，透過主成分分析法找出漫反射光譜中三大主要成分，再以擬合方式取得投影量對應帶氧血紅素、不帶氧血紅素與膽紅素濃度三者的關係，使用台大宋孔彬老師實驗室提供的類神經系統擬合出的濃度資訊可應用於受試者的生理數值分析上，建立瘀傷形成及癒合的時間模型，而後擴大受試者的基底可以將時間模型更完善，並應用在生醫研究上。

摘要(英)

Optical detection technology is widely used in biomedical research because it has the advantage of not damaging the organism itself. In recent years, with the gradual rise of health awareness, non-invasive technology has gradually been applied to the analysis of physiological indexes of the human body.
Diffuse reflectance spectroscopy (DRS) is the most commonly used optical detection technology on the human body. Through the analysis of spectral performance, reflectance and concentration, a number of subcutaneous tissue data that cannot be observed with the naked eye can be obtained, such as Oxygenated Hemoglobin, Deoxygenated Hemoglobin, bilirubin, biliverdin etc. These data help to understand the subject′s current degree of bruises, as well as the healing and formation time of the bruises.
This study uses a diffuse reflectance spectroscopy measurement system coupled with principal component analysis to obtain changes in subcutaneous tissue content through a neural network, and then conducts physiological numerical analysis. By collecting subjects with bruises, the diffuse reflectance spectrum and two-dimensional images of the injured area were collected, and the four main components in the diffuse reflectance spectrum were found through principal component analysis, and then the projection volume corresponding bands were obtained by fitting. The relationship between oxygenated hemoglobin, non-oxygenated hemoglobin and bilirubin concentration. The concentration information fitted using the neural system provided by Professor Song Kong Bin′s laboratory at National Taiwan University can be applied to the analysis of the physiological values of the subjects to establish blood stasis. Time model of injury formation and healing, and then expanding the basis of subjects can improve the time model and apply it to biomedical research.

關鍵字(中)

★ 漫反射光譜
★ 瘀傷
★ 蒙地卡羅
★ 主成分分析法

關鍵字(英)

★ Diffuse reflectance spectroscopy
★ Bruise skin
★ Monte Carlo
★ Principal components analysis

論文目次

中文摘要.................................................................................................................................................. I
Abstract.................................................................................................................................................. II
目錄........................................................................................................................................................ III
圖目錄.................................................................................................................................................... IV
表目錄.................................................................................................................................................... VI
第一章緒論...................................................................................................................................... 1
1-1 研究動機與目的...................................................................................................................... 1
1-2 文獻回顧與探討...................................................................................................................... 1
1-3 論文架構.................................................................................................................................. 5
第二章實驗原理與分析方法.......................................................................................................... 6
2-1 漫反射的光學特性與應用...................................................................................................... 6
2-2 人體皮膚的組成與漫反射光譜.............................................................................................. 9
2-3 主成分分析之原理................................................................................................................ 14
2-4 蒙地卡羅與類神經網路之原理............................................................................................ 16
第三章實驗方法............................................................................................................................ 19
3-1 二維影像的取得.................................................................................................................... 19
3-2 漫反射光譜量測系統............................................................................................................ 20
3-3 樣本處理與採樣方式............................................................................................................ 24
第四章實驗結果............................................................................................................................ 26
4-1 二維影像色度分析................................................................................................................ 26
4-2 仿體光譜的校正與光纖選擇................................................................................................ 30
4-3 漫反射光譜與主成分分析結果............................................................................................ 34
4-4 主成分分析應用於樣本之生理指數分析............................................................................ 42
4-4-1 主成分與擬合濃度之關聯性.......................................................................................... 42
4-4-2 瘀傷顏色變化與主成分變化之差異 .............................................................................. 48
第五章結論.................................................................................................................................... 52
參考文獻............................................................................................................................................... 53

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指導教授

陳思妤(Szu-Yu Chen)

審核日期

2024-8-21

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