Phase statistics approach to human ventricular fibrillation

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题名:	Phase statistics approach to human ventricular fibrillation
作者:	Wu,MC;Watanabe,E;Struzik,ZR;Hu,CK;Yamamoto,Y
贡献者:	數據分析方法研究中心
关键词:	IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS;SUDDEN CARDIAC DEATH;TIME-SERIES ANALYSIS;WAVELET ANALYSIS;DYNAMICS;SURFACES;CASCADE;ARREST
日期:	2009
上传时间:	2010-06-29 19:12:33 (UTC+8)
出版者:	中央大學
摘要:	Ventricular fibrillation (VF) is known to be the most dangerous cardiac arrhythmia, frequently leading to sudden cardiac death (SCD). During VF, cardiac output drops to nil and, unless the fibrillation is promptly halted, death usually ensues within minutes. While delivering life saving electrical shocks is a method of preventing SCD, it has been recognized that some, though not many, VF episodes are self-terminating, and understanding the mechanism of spontaneous defibrillation might provide newer therapeutic options for treatment of this otherwise fatal arrhythmia. Using the phase statistics approach, recently developed to study financial and physiological time series, here, we reveal the timing characteristics of transient features of ventricular tachyarrhythmia (mostly VF) electrocardiogram (ECG) and find that there are three distinct types of probability density function (PDF) of phase distributions: uniform (UF), concave (CC), and convex (CV). Our data show that VF patients with UF or CC types of PDF have approximately the same probability of survival and nonsurvival, while VF patients with CV type PDF have zero probability of survival, implying that their VF episodes are never self-terminating. Our results suggest that detailed phase statistics of human ECG data may be a key to understanding the mechanism of spontaneous defibrillation of fatal VF.
關聯:	PHYSICAL REVIEW E
显示于类别:	[數據分析方法研究中心 ] 期刊論文

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