DNA methylation profiles in monozygotic and dizygotic twins

NCU Institutional Repository > 生醫理工學院 > 系統生物與生物資訊研究所 > 期刊論文 > Item 987654321/27740

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.lib.ncu.edu.tw/handle/987654321/27740

题名:	DNA methylation profiles in monozygotic and dizygotic twins
作者:	Kaminsky,ZA;Tang,T;Wang,SC;Ptak,C;Oh,GHT;Wong,AHC;Feldcamp,LA;Virtanen,C;Halfvarson,J;Tysk,C;McRae,AF;Visscher,PM;Montgomery,GW;Gottesman,II;Martin,NG;Petronis,A
贡献者:	系統生物與生物資訊研究所
关键词:	EPIGENETIC DIFFERENCES;GENE;DISCORDANT;DISEASE;GENOME;ASSOCIATION
日期:	2009
上传时间:	2010-06-29 19:26:50 (UTC+8)
出版者:	中央大學
摘要:	Twin studies have provided the basis for genetic and epidemiological studies in human complex traits(1,2). As epigenetic factors can contribute to phenotypic outcomes, we conducted a DNA methylation analysis in white blood cells (WBC), buccal epithelial cells and gut biopsies of 114 monozygotic (MZ) twins as well as WBC and buccal epithelial cells of 80 dizygotic (DZ) twins using 12K CpG island microarrays(3,4). Here we provide the first annotation of epigenetic metastability of similar to 6,000 unique genomic regions in MZ twins. An intraclass correlation (ICC)-based comparison of matched MZ and DZ twins showed significantly higher epigenetic difference in buccal cells of DZ co-twins (P = 1.2 x 10(-294)). Although such higher epigenetic discordance in DZ twins can result from DNA sequence differences, our in silico SNP analyses and animal studies favor the hypothesis that it is due to epigenomic differences in the zygotes, suggesting that molecular mechanisms of heritability may not be limited to DNA sequence differences.
關聯:	NATURE GENETICS
显示于类别:	[系統生物與生物資訊研究所] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	861	检视/开启

在NCUIR中所有的数据项都受到原著作权保护.

社群 sharing

数据加载中.....