The Effects of Misclassification in Studies of Gene-Environment Interactions

NCU Institutional Repository > 理學院 > 統計研究所 > 期刊論文 > Item 987654321/27782

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.lib.ncu.edu.tw/handle/987654321/27782

题名:	The Effects of Misclassification in Studies of Gene-Environment Interactions
作者:	Cheng,KF;Lin,WJ
贡献者:	統計研究所
关键词:	POPULATION STRATIFICATION;GENOTYPING ERROR;SUSCEPTIBILITY;ASSOCIATION
日期:	2009
上传时间:	2010-06-29 19:33:30 (UTC+8)
出版者:	中央大學
摘要:	Differential Misclassification of genotype may cause usual tests producing spurious gene-disease associations or unable to detect important associations. To control for the resulting bias, many model-based approaches have been proposed using validation data. However, the effects of joint misclassification of genotype and environmental exposure in studies of gene-environment interaction are still not clear. In this paper, we focus on quantifying the effects of misclassification in case-control and case-only studies of interaction without specifying any model for misclassification probabilities. By using the derived results, we are able to identify important conditions, under which the presence of misclassification does not introduce bias in case-control or case-only studies. We have conducted a simulation study, using parameter values from real examples, to confirm our theoretical findings. The simulation results show that under the identified conditions, many regular tests for the hypothesis of no interaction maintain correct type I error rates in the presence of differential misclassification. However, their powers may be decreased as misclassification error rates increase. Copyright (C) 2008 S. Karger AG, Basel
關聯:	HUMAN HEREDITY
显示于类别:	[統計研究所] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	460	检视/开启

在NCUIR中所有的数据项都受到原著作权保护.

社群 sharing

数据加载中.....