超低溫液態氮生物試片儲存系統的硬體研發; Hardware Development of An Innovative Biospecimen Storage System with Liquid Nitrogen

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题名:	超低溫液態氮生物試片儲存系統的硬體研發;Hardware Development of An Innovative Biospecimen Storage System with Liquid Nitrogen
作者:	李育菁;Yu-Ching Li
贡献者:	機械工程研究所
关键词:	有限元素;液態氮儲存槽;幹細胞;臍帶血;umbilical cord blood;stem cell;liquid nitrogen storage tank;finite element
日期:	2009-07-02
上传时间:	2009-09-21 12:06:23 (UTC+8)
出版者:	國立中央大學圖書館
摘要:	生物醫學科技隨時間不斷的向上發展，其主要的目的在於增進人類的壽命與更優質的生活，以商業角度來看來更是一塊大餅，在人力與物力不斷的投入下，此產業成為新世紀快速發展的另類明星科技產業。目前國內業者使用的液態氮超低溫(-196℃)儲存設備分為傳統開蓋式與機械自動式兩種。傳統開蓋式例如：Taylor-Wharton之K系列、LABS系列，CHART之MVE Eterne系列…等；機械自動式例如Cryo-Cell之Cryo-Cell系統、Thermogenesis 的BioArchive系統…等。本篇論文主要的研究目的，是延續開發本實驗室設計的大容量液態氮超低溫(-196℃)儲存設備，參考其它相同功能的產品與本實驗室設計的的第一代小容量儲存系統，保留其使用上與保存上的優點並改善其缺點，設計出一個更適合存放生物試片的超低溫(-196℃)儲存設備，以下簡稱：第二代系統。研究過程中主要是在硬體的設計分析與製造測試，設計分析方面：使用3D繪圖軟體將第二代系統建模型，再使用套裝軟體進行相關結構複雜處進行有限元素分析，分析設計上的結構強度，在還沒打樣製造前，先行了解到設計上是否有缺失的地方，減少成本與製造上的麻煩；製造測試方面：由於本設備目標走向產品化，在設計上除了符合目的需求外，也需同時兼顧製造上的方法與程序，如果製造流程上很困難，對於準產品來說是最大的致命傷。有前面設計分析當背景，也必須實際的測試，才能對第二代系統的零件有更進一步的性能掌控與缺點改善，以上所述兩大點，皆是本論文最重要的研究目的與方向。研究的成果：有限元素分析與打樣結果顯示第二代的系統的主要精神是可行的，比第一代的系統更具模組性、擴充性，最大容量也可增加到2944個儲放空間。在不使用電力的情形下，簡單的機構設計，使試片做單一的存取，此方式可以避免影響到其它試片的生物活性，最後加上軟體界面互相搭配達到最佳的產品設計。 Biomedical Technology has been continuously developed as time goes by. The main purpose is to increase the life-span of human being and to provide better lives, when we look from business aspect, there’s a great market behind it. After lots of manpower and material resources are involved in, this field will become the fast-developing and fascinating industry. At this moment, the mostly used liquid nitrogen specimen storage systems can be divided into two types, the Traditional Lid-Open type and Auto-Mechanics type. The examples of Traditional Lid-Open type are the K series and LABS series of Taylor-Wharton, the MVE Eterne series of CHART…etc.; the Cryo-Cell of Cryo-Cell systems and the Thermogenesis of BioArchive system…etc. are in the Auto-Mechanics category. This main purpose of this essay is to continue developing the mass volume liquid nitrogen specimen storage systems designed in this laboratory. Taking the reference of other products with the same functions and the proto small volume storage system designed in this laboratory, reserving the advantages of using and preserving, also improving the defects, to design a better ultra-low temperature (-196℃) storage system, which will be referred to The Second Generation System. In the research, the effort was on design-analyze and manufacture testing. For design-analyze, the model of The Second Generation System is built up by using 3D drafting software, and then used pack software to process the finite element analyzing of the correlated and complex construction, also analyzing the strength of the structure. Before actually manufacturing, those steps helped realize if there are any defects of the design and reduced the budget and eliminated the trouble. And for manufacturing testing, the goal of this system is mass producing, the design must not only fit in the requirement, but also take care the method and the procedure of manufacturing. If it’s difficult for manufacturing process, then it’s also very fatal to pre-products. With the data of design-analyze for support, and after times of experiments, the performance control and the defects improvement go further. The design-analyze and the manufacture testing are the major purposes and directions of the essay. The result of the research: the finite element analyzing and the result of casting showed the main spirit of The Second Generation System feasible. Comparing to the proto systems, The Second Generation System is with the properties of modulizing and expanding, the volume can also be increased to 2944 storage compartments. Without any electricity, simple mechanical design makes the specimen storing and drawing step signalized. The prevention of influencing the biological activity of other specimen is achieved with this method. At the end, synchronizing the procedures with software interface will optimize the product design.
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