Cox模型與AFT模型的相互誤判對於迴歸參數影響之探討; The effect of misspecification of regression parameters between Cox and AFT model

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/48223

Title:	Cox模型與AFT模型的相互誤判對於迴歸參數影響之探討;The effect of misspecification of regression parameters between Cox and AFT model
Authors:	李家任;Jia-ren Li
Contributors:	統計研究所
Keywords:	Cox模型;誤判模型;AFT模型;擴充風險模型;史丹佛心臟移植資料;Misspecified model;Cox model;AFT model;Extended hazard model;Stanford heart transplant data
Date:	2011-06-24
Issue Date:	2012-01-05 14:41:54 (UTC+8)
Abstract:	在存活分析中，使用誤判模型 (misspecified model)配適存活資料時，常會影響存活模型中的參數估計值，而且與正確模型配適存活資料相比較的話，甚至會導致其共變數對風險函數的顯著性產生不同的結果，所以本篇藉由統計模擬，分別在時間獨立及時間相依的共變數存活模型下，使用Cox模型、AFT模型及擴充風險模型配適存活資料，我們所感興趣的是Cox模型與AFT模型的相互誤用是否會對共變數的迴歸參數產生影響，而我們的方法是利用擴充風險模型來做Cox模型及AFT模型誤判的研究，而主要的原因在於擴充風險模型為一個較廣義的模型，它同時包含了Cox模型及AFT模型的特性。在實例分析的部份，我們討論台灣愛滋病病患資料 (Taiwan AIDS data)以及Miller (1981)所分析的史丹佛心臟移植資料 (Stanford heart transplant data)。在這兩筆資料中，我們分別使用Cox模型及AFT模型時，觀察其共變數對於風險函數的影響程度。 In the survival analysis, when we use the misspecified model to fit the survival data, it often affects the parameter estimates of the survival model, and this even leads to produce different results of significance from covariates on the hazard function, if we compare with the result of using the correct model to fit the survival data. Therefore, through statistical simulation under the time-independent covariate of survival model and the time-dependent covariate of survival model, we use Cox model, AFT model, and extended hazard model to fit the survival data, and we have interest in the effects of misspecification of regression parameters between Cox and AFT model. Our approach is to use extended hazard model to discuss the effect of misspecification between Cox and AFT model mainly, because the extended hazard model is a more generalized model, which includes the features of Cox model and AFT model. In the real data analysis, we analyze Stanford heart transplant data from Miller (1981), and the Taiwan AIDS data. We use Cox model and AFT model to analyzed these data, and to observe the degree of influence from the covariate on the hazard function.
Appears in Collections:	[Graduate Institute of Statistics] Electronic Thesis & Dissertation

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