Liver Development and Cancer Formation in Zebrafish

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Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/50831

Title:	Liver Development and Cancer Formation in Zebrafish
Authors:	Lu,JW;Hsia,Y;Tu,HC;Hsiao,YC;Yang,WY;Wang,HD;Yuh,CH
Contributors:	生命科學系
Keywords:	HEPATITIS-B-VIRUS;HUMAN HEPATOCELLULAR CARCINOMAS;ACID-BINDING PROTEIN;TUMOR-SUPPRESSOR GENES;GERM-LINE TRANSMISSION;BETA-CATENIN GENE;L-FABP GENE;X-PROTEIN;TRANSGENIC ZEBRAFISH;HBX PROTEIN
Date:	2011
Issue Date:	2012-03-27 18:10:57 (UTC+8)
Publisher:	國立中央大學
Abstract:	Liver is the largest organ in the human body, and it regulates many physiological processes. Many studies on liver development in different model organisms have demonstrated that the mechanism of hepatogenesis is conserved in vertebrates. The identification of the genes and regulatory pathways involved in liver formation provides a basis for the diagnosis of liver diseases and therapeutic interventions. Hepatocellular carcinoma is the third leading cause of mortality worldwide. In the last decade, genetic alterations, which include the gain and loss of DNA, as well as mutations and epigenomic changes, have been identified as important factors in liver cancer. Many genetic pathways are dysregulated during carcinogenesis. Here, we review the gene regulatory networks that underlie liver organogenesis and the dysregulation of these pathways in liver cancer. The genes and pathways involved in hepatogenesis and liver cancer are largely conserved between zebrafish and humans, making this an ideal model organism for the study of this disease. A better understanding of liver development may aid in the development of new diagnostic and therapeutic approaches to liver cancer. Birth Defects Research (Part C) 93: 157-172, 2011. (C) 2011 Wiley-Liss, Inc.
Relation:	BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS
Appears in Collections:	[Department of Life Science] journal & Dissertation

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