A robust TDT-type association test under informative parental missingness

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/51850

Title:	A robust TDT-type association test under informative parental missingness
Authors:	Chen,JH;Cheng,KF
Contributors:	統計研究所
Keywords:	HAPLOTYPE RELATIVE RISK;TRANSMISSION DISEQUILIBRIUM TEST;LINKAGE DISEQUILIBRIUM;ADMIXTURE;DESIGNS;DISEASE;TRIOS
Date:	2011
Issue Date:	2012-03-27 19:07:38 (UTC+8)
Publisher:	國立中央大學
Abstract:	Many family-based association tests rely on the random transmission of alleles from parents to offspring. Among them, the transmission/disequilibrium test (TDT) may be considered to be the most popular statistical test. The TDT statistic and its variations were proposed to evaluate nonrandom transmission of alleles from parents to the diseased children. However, in family studies, parental genotypes may be missing due to parental death, loss, divorce, or other reasons. Under some missingness conditions, nonrandom transmission of alleles may still occur even when the gene and disease are not associated. As a consequence, the usual TDT-type tests would produce excessive false positive conclusions in association studies. In this paper, we propose a novel TDT-type association test which is not only simple in computation but also robust to the joint effect of population stratification and informative parental missingness. Our test is model-free and allows for different mechanisms of parental missingness across subpopulations. We use a simulation study to compare the performance of the new test with TDT and point out the advantage of the new method. Copyright (C) 2010 John Wiley & Sons, Ltd.
Relation:	STATISTICS IN MEDICINE
Appears in Collections:	[Graduate Institute of Statistics] journal & Dissertation

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