Identification of the minimum effective dose based on weighted Kaplan-Meier statistics

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/51870

Title:	Identification of the minimum effective dose based on weighted Kaplan-Meier statistics
Authors:	Chang,YM;Chen,YI
Contributors:	統計研究所
Keywords:	CENSORED SURVIVAL-DATA;TESTING PROCEDURES;INFERENCE;TRIALS
Date:	2011
Issue Date:	2012-03-27 19:08:01 (UTC+8)
Publisher:	國立中央大學
Abstract:	Testing procedures are considered for identifying the minimum effective dose (MED) in a dose-response study with randomly right-censored survival data, where the MED is defined to be the smallest dose level under study that has survival advantage over the zero dose control. The proposed testing procedures are implemented in a step-down manner together with three different types of weighted Kaplan-Meier statistics. Comparative results of a Monte Carlo error rate and power/bias study for a variety of survival and censoring distributions are then presented and discussed. The application of the proposed procedures is finally illustrated for identifying the MED of the diethylstilbestrol in the treatment of prostate cancer.
Relation:	JOURNAL OF STATISTICAL COMPUTATION AND SIMULATION
Appears in Collections:	[Graduate Institute of Statistics] journal & Dissertation

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	650	View/Open

社群 sharing