Identification of the minimum effective dose based on weighted Kaplan-Meier statistics

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题名:	Identification of the minimum effective dose based on weighted Kaplan-Meier statistics
作者:	Chang,YM;Chen,YI
贡献者:	統計研究所
关键词:	CENSORED SURVIVAL-DATA;TESTING PROCEDURES;INFERENCE;TRIALS
日期:	2011
上传时间:	2012-03-27 19:08:01 (UTC+8)
出版者:	國立中央大學
摘要:	Testing procedures are considered for identifying the minimum effective dose (MED) in a dose-response study with randomly right-censored survival data, where the MED is defined to be the smallest dose level under study that has survival advantage over the zero dose control. The proposed testing procedures are implemented in a step-down manner together with three different types of weighted Kaplan-Meier statistics. Comparative results of a Monte Carlo error rate and power/bias study for a variety of survival and censoring distributions are then presented and discussed. The application of the proposed procedures is finally illustrated for identifying the MED of the diethylstilbestrol in the treatment of prostate cancer.
關聯:	JOURNAL OF STATISTICAL COMPUTATION AND SIMULATION
显示于类别:	[統計研究所] 期刊論文

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