生物對等性之貝氏檢定

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/60911

Title:	生物對等性之貝氏檢定
Authors:	謝佩倢;Sie,Pei-jie
Contributors:	統計研究所
Keywords:	生物對等性試驗;兩期雙序列交叉設計;生體可用性;貝氏方法;穩健隨機效應模式;Bioequivalence test;2×2 crossover design;Bioavailability;Bayesian method;Robust random effects model
Date:	2013-07-22
Issue Date:	2013-08-22 12:06:30 (UTC+8)
Publisher:	國立中央大學
Abstract:	本文研究在兩期雙序列交叉設計之下，受試藥及專利藥的生物對等性檢定。如果之前具有類似學名藥的試驗，則研究者具備此一受試藥生體可用性的先驗知識。所以，本文考慮使用貝氏方法分析生體可用性衡量值的穩健隨機效應模式，進行兩種藥物的貝氏生物對等性檢定。本文除了利用實例說明所提穩健模式及貝氏生物對等性檢定的應用，並且使用模擬方法研究在各種可能的隨機效應模式之下，此一貝氏生物對等性檢定的表現。 The article considers the bioequivalence test between the test drug and patent drug under a 2×2 crossover design. If there have been some generic drugs under study, then prior information about the bioavailability of the test drugs would be available. Therefore, this article considers a Bayesian test for the bioequivalence of the two drugs based on a robust random effects model for the estimated bioavailability parameters. A real data is illustrated based on the proposed Bayesian bioequivalent test. Finally, a simulation study is implemented to investigate the performance of the proposed test.
Appears in Collections:	[Graduate Institute of Statistics] Electronic Thesis & Dissertation

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