利用橫跨複分解和環閉合 複分解反應來合成 架橋菸酸酯;Using cross metathesis and ring closing metathesis reaction for sythesis bridged nicotinate

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/6160

Title:	利用橫跨複分解和環閉合複分解反應來合成架橋菸酸酯;Using cross metathesis and ring closing metathesis reaction for sythesis bridged nicotinate
Authors:	黃如評;Yu-Ping Hung
Contributors:	化學研究所
Keywords:	複分解反應;Cross Metathesis
Date:	2005-06-24
Issue Date:	2009-09-22 10:14:23 (UTC+8)
Publisher:	國立中央大學圖書館
Abstract:	中文摘要最近幾年，橫跨複分解(CM)和環閉合複分解(RCM)反應已經很廣泛應用在有機合成。我們利用橫跨複分解(CM)與環閉合複分解 (RCM)反應來合成架橋菸鹼(bridged nicotinate) 化合物1。其中我們發現，如使用化合物27、29、31、34、35經由環閉合複分解(RCM)反應不能形成分子內十四圓環化合物，而得到的是兩個分子間的複分解和環起來的化合物。但使用化合物37與1,5-己二烯進行橫跨複分解(CM)與環閉合複分解(RCM)反應則可得到化合物50，再經由氫化得到化合物1。化合物1，可以廣泛使用在合成具有鏡像選擇性的化合物。 In recent years， olefin cross metathesis(CM) and ring-closing metathesis(RCM) have emerged as a powerful and convenient synthetic technique in organic chemistry。 We use CM and RCM to from bridged nicotinate (compound 1). Among we to discover, if use compound 27、29、31、34、35 via RCM not to form fourteen ring compound，but obtain two compound between CM and RCM reaction。But use compound 37 with 1,5-hexadiene to proceed CM and RCM reaction， to be obtain compound 50，and then via hydrogenation to obtain compound 1。 Compound 1，can popularly use to have enantioselection compound in synthesis。
Appears in Collections:	[Graduate Institute of Chemistry] Electronic Thesis & Dissertation

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