本研究一開始以TPD與溴苯為反應物,嘗試不同的催化劑、配位基、鹼、溶劑,以找到最佳化條件,其中,我們發現溶劑的極性對於反應的轉換率具有決定性的影響。利用找到的最佳化條件,TPD或其衍生物與具有各種不同官能基的芳香基溴化物可順利地進行鈀催化碳氫鍵活化的反應。此反應中對於官能基容忍性非常好,像是酯基、腈基、酮基、醛基還有含鹵素基都是可以被容忍的。 ;We demonstrate a step-economical and viable synthetic alternative to access a series of thieno[3,4-c]pyrrole-4,6-dione (TPD)-based π-conjugated molecules through Pd-catalyzed direct C-H arylations. A comprehensive synthetic study including the screening of various kinds of palladium catalysts, ligands, and bases is reported. Under the optimum reaction conditions, TPD and its common derivatives underwent efficient and mild direct C-H arylations with a variety of functionalized bromoarenes. Functional groups such as ester, nitrile, ketone, aldehyde, and halide were well-tolerated, which substantially extended the reaction scope. We wish the reported method would provide materials scientists a relatively greener synthetic route to efficiently prepare the TPD-containing π-functional materials.