本論文提出一種新型之D型光纖生化感測方法及系統，其係採用可產生電漿共振效果之光纖感測器，將待檢物（例如：酒精、葡萄糖等等溶液）放置於該光纖感測器上，再將光源導入光纖感測器後，利用外差干涉術測量得到其干涉信號之相位差；或利用其衰減全反射的特性，可量得其輸出端的光強度信號。如此，我們便可測得待測物的折射率或是其他與待測物有關之參數。 此光纖感測器具有體積小、易於量測、可於遠端遙測、只需少許檢體、高解析度、高靈敏度以及可作體內量測等等的優點。此外，其靈敏度可藉由量測角度予以調整，因此此可調式靈敏度的特性，可廣泛用於不同介質的量測。值得一題的是，其靈敏度可達 的折射率單位，且實驗結果與電腦模擬結果呈現一致的現象。 由於此D型光纖生化感測器具有如此多的優點，因此我們可將其推廣應用於醫學檢測、生化檢測、化學藥品以及生醫光電等等領域。相信，其對未來生物醫學技術必有相當的幫助。 In the dissertation, a D-type optical fiber biosensor based on the surface plasmon resonance (SPR) technology is proposed. The optical fiber biosensor is a novel sensing device based on the surface plasmon resonance (SPR) technology or/and heterodyne interferometry. In the sensing mechanism, we only drop a little tested sample (e.g., alcohol, C6H12O6 solution etc.) on the sensing surface of the sensor. The refractive indices and the other parameters of the tested medium can be achieved by measuring the phase difference variations and the light intensity from the output of the sensor. The senor has some merits, e.g., small size, smaller sample volume, easy measurement and suitable for in vivo test etc. Besides, the D-type optical fiber biosensor has the tunable high sensitivity only if we choose different incident angle. From experimental results, it is evident that they are in good correspondence with theoretical results. Its sensitivity can reach 0.000002 refractive index unit (RIU). To sum up, it may be a useful sensor device for the researchers in the related fields, especially in biophotonics. Perhaps it will contribute to the human beings significantly in the future.
