具鏡像選擇性合成(+)-brevipolide H

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/71371

Title:	具鏡像選擇性合成(+)-brevipolide H
Authors:	陳慶濃;Chen,Ching-Nung
Contributors:	化學學系
Keywords:	有機化學;天然物合成;全合成;抗癌藥物;organic chemistry;natural product synthesis;total synthesis;anti cancer
Date:	2016-08-15
Issue Date:	2016-10-13 12:47:16 (UTC+8)
Publisher:	國立中央大學
Abstract:	本篇論文是以對稱的雙烯醇化合物2作為起始物，利用Sharpless不對稱環氧化反應，合成高鏡像選擇性的兩個不對稱中心。將兩鏡像化合物修飾後，經由交叉置換反應連接成主要骨架8，經多步反應包括環氧三環的開環、酯化反應、環烷化反應、氧化反應、環閉合置換反應等官能基化，成功合成天然物(+)-brevipolide H及其家族成員(+)-brevipolide G。;By way of Sharpless epoxidation of enta-1,4-dien-3-ol, both enantiomerically pure epoxides were converted to the corresponding　olefins for cross metathesis. Subsequent transformations, including epoxide ring opening, esterifications,cyclopropanation, oxidation and ring-closing metathesis, provided the target molecule. This synthesis successfully addresses previous shortcomings in preparing brevipolides.
Appears in Collections:	[Graduate Institute of Chemistry] Electronic Thesis & Dissertation

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