The Research of Material Deposition Process for Bio-scaffold Fabrication in Tissue Engineering Applications

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题名:	The Research of Material Deposition Process for Bio-scaffold Fabrication in Tissue Engineering Applications
作者:	范玉海;Pham, Ngoc-Hai
贡献者:	機械工程學系
关键词:	組織工程支架;低溫沉積製造;點膠系統;Tissue Engineering Scaffold;Low-temperature Depositon Manufacturing;Dispensing System
日期:	2017-11-09
上传时间:	2018-01-16 11:07:22 (UTC+8)
出版者:	國立中央大學
摘要:	在組織工程技術的最新進展中，已經能讓醫生能夠處理一些先前較難治療的病症。開發這種技術時，也已經製備了具有可控孔徑和孔隙率的支架，以研究細胞相互作用，如細胞增殖和分化。在本研究中，描述使用我們所開發的低溫沉積製造系統所製作出的支架。而該系統使用能夠製造三維微結構的技術並需要多種系統的整合，包括運動卡控制、移動系統、低溫系統、材料分配系統。另一方面，這項研究也通過利用這種低溫沉積製造的方式來研究我們所使用之材料(PLA)的沉積過程，並嘗試用不同方法去做實驗分析，如：梯形移動，片段擠出和可變移動速度的擠出分析以及提高支架寬度均勻的品質，特別是位於轉角處的材料過度堆積。 ;Recent developments in tissue-engineering techniques allow physicians to treat a range of previously untreatable conditions. In the development of such techniques, scaffolds with a controllable pore size and porosity have been manufactured to investigate cell interaction effects such as cell proliferation and differentiation. In this study, we describe the fabrication of scaffolds using a low-temperature deposition manufacturing system that we developed. This systems uses technology that enables the manufacture of three-dimensional microstructures and required the combination of several technologies, including motion card control (NI-motion card, National Instruments), movement system (Linmot system), low-temperature system, material dispesing system (Ultimus IV, NORDSON). In the other hand, this research will be researched the material (PLA) deposition process by this low-temperature deposition manufacturing and try to use our method such as: the trapezoidal move, the segment extrusion and the extrusion with variable moving velocities to analysis and improve the quality of the uniform width strands of scaffold and specially the over-accumulation of material located in the corner.
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