開發可生物降解的完全磷酸膽鹼水凝膠;Development of Biodegradable Complete Phosphorylcholine Hydrogel

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题名:	開發可生物降解的完全磷酸膽鹼水凝膠;Development of Biodegradable Complete Phosphorylcholine Hydrogel
作者:	吳氏蘭香;Huong, Ngo Thi Lan
贡献者:	生醫科學與工程學系
关键词:	雙離子交聯劑;磷酸膽鹼;水凝膠;可降解;Zwitterionic crosslinker;phosphorylcholine;hydrogel;degradable
日期:	2021-01-18
上传时间:	2021-03-18 16:52:22 (UTC+8)
出版者:	國立中央大學
摘要:	水凝膠是一種三維聚合物結構，具有高含水量、柔軟性、柔韌性、與生物相容性等特殊性質，因此水凝膠成為一種有潛力的生醫材料。水凝膠適合應用於藥物傳遞系統、生醫感測器、組織工程支架、生物膜、人工器官、傷口癒合敷料、隱形眼鏡等。[1] 其中，在控制釋放藥物系統及植入式醫療器材的應用中，水凝膠的生物降解能力是一項重要的性質。[3] 因此，我們展示一項新型生物可降解的雙離子交聯劑，藉由合成2-[2-{2-(methacryloyloxy)ethyldimethylammonium}ethyl phosphate] 2-ethyl disulfide (MPCSS)，以提供可經由還原而降解的雙硫鍵結。經由結合2-甲基丙烯?氧基乙基磷?膽鹼(MPC)及MPCSS交聯劑，以形成完全磷酸膽鹼的雙離子水凝膠，而此水凝膠展現生物可相容及生物可降解的特性。我們深入探討完全磷酸膽鹼的雙離子水凝膠，了解其機械性質、生物相容性及抗汙貼附的能力。此外，我們探討MPCSS交聯劑水凝膠的重量損失，以衡量其可降解的特性。在這項研究中，我們初步探討了磷酸膽鹼水凝膠的注射應用.;Hydrogel, a three-dimensional polymer structure, has been discovered as a good biomaterial with specific properties, such as high water content, softness, flexibility, and biocompatibility. The hydrogels are great candidates for drug delivery systems, biosensors, tissue engineering scaffolds, physiological membranes, artificial organs, wound healing dress, and contact lenses. [1] Moreover, with applications for control drug delivery or implantable medical devices, the biodegradable property is in high demand. Hence, a novel zwitterionic degradable crosslinker, 2-[2-{2-(methacryloyloxy)ethyldimethylammonium}ethyl phosphate] 2-ethyl disulfide (MPCSS) was synthesized to provide a disulfide linkage for degradation via reduction. A full zwitterionic phosphorylcholine (PC) hydrogel, which is phospholipid-inspired, biocompatible and biodegradable, was created by combining zwitterionic monomer 2-Methacryloyloxyethyl phosphorylcholine (MPC) and MPCSS crosslinker. Herein, the mechanical, biocompatible and antifouling properties of the full zwitterionic PC hydrogels were investigated. Besides, the degradation characteristic of MPCSS-crosslinked hydrogel was evaluated through their weight loss. In this research, the injectable application of PC hydrogel is preliminarily explored.
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