聚醚醚酮(Polyetheretherketone, PEEK)屬於熱塑性高分子聚合物，因此其特性非常適合作為積層製造技術的材料，且PEEK也在近幾年來非常頻繁的被運用在生物醫療方面的領域，尤其是人體植入物，由於其具備良好的生物相容性與機械強度，且PEEK與金屬植入物相較之下其彈性模數較接近人體皮質骨，且PEEK具備射線可穿透性並不會產生偽影，這在醫療方面相當重要，若產生偽影可能會造成術後的追蹤與診斷發生困難，也因此PEEK近年來在人體植入物這部分成為金屬替代材料的熱門選擇，但PEEK也存在一個相當大的缺陷，由於PEEK屬於生物惰性，因此造成PEEK在植入人體後其骨分化、細胞的附著與增殖的效果均不太良好，因此需要透過表面改質來增加其生物活性，本研究開發出了一種表面改質的方法，成功利用熔融沉積成型系統列印PEEK試片使其表面覆蓋一層聚乳酸-羥基磷灰石(PLA-HA)材料，隨後透過二氯甲烷溶解大部分的PLA材料，讓PEEK試片表面僅留下HA粉末與少量的PLA。;Polyetheretherketone is a thermoplastic polymer, so its characteristics are very suitable as a material for multilayer manufacturing technology. In recent years, PEEK has also been frequently used in the field of biomedicine, especially human implants. Because of its good biocompatibility and mechanical properties, PEEK’s elastic modulus is closer to human cortical bone than metal implants. PEEK is radiolucent and does not produce artifacts. That is important to medical treatment, if artifacts are generated, it may be difficult to track and diagnose after surgery. Therefore, PEEK has become a popular choice to replace metal materials in human implants in recent years. However, PEEK also has a considerable defect. PEEK is biologically inert, so the effects of PEEK′s bone differentiation, cell adhesion and proliferation after implantation in the human body are not very good. Therefore, the surface modification is needed to increase its biological activity. This research has developed a surface modification method. The FDM system was successfully used to print the PEEK specimen to cover its surface with a layer of PLA-HA material, and then dissolve most of the PLA material through methylene chloride, leaving only HA powder and a small amount of PLA on the surface of the PEEK specimen.
