糜爛性食道炎成因之探討

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許含熏(Han-Hsun Hsu) 查詢紙本館藏

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統計研究所

論文名稱

糜爛性食道炎成因之探討
(Cause of the erosive esophagitis)

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摘要(中)

台灣的胃食道逆流病患者日益增多，此疾病對病患身心及生活品質影響重大，消耗的診斷及治療醫療資源也極為可觀〔1、2、3〕。本篇論文的目的就是要去探討會導致糜爛性食道炎的相關危險因子。
本文利用卡方檢定和兩樣本的 t檢定探討年齡、性別、抽煙、喝酒、瓣閥、體重、腰圍、身體質量指數、麻醉劑量和收縮劑與糜爛性食道炎的關聯性，再利用邏輯斯迴歸與累積邏輯斯迴歸分別探討發生糜爛性食道炎與危險因子的勝算比。研究分析發現年齡，在顯著水準為0.05之下，並不會顯著影響增加得到糜爛性食道炎的機會。其顯著性最高的兩個自變數為有抽煙和胃食道皮瓣者，在排除年齡、性別、瓣閥和身體質量指數的影響下，有抽煙的人得到糜爛性食道炎的機會比例較沒有抽煙高5.342（95% 信賴區間（confidence interval ，CI）=2.908~9.813，P–值<0.0001）。在排除年齡、性別、抽煙和身體質量指數的影響下，具有不正常胃食道皮瓣者得到糜爛性食道炎的機會比例較正常胃食道皮瓣者高11.223（95% CI=3.200~39.364，P–值=0.0002）。而利用累積邏輯斯迴歸也同樣得到其顯著性最高的兩個自變數為有抽煙者及具有不正常胃食道皮瓣者，有較高的機會得到糜爛性食道炎。此外，病患被觀察食道時間的長短，研究分析發現觀察的時間越久越能正確看出糜爛性食道炎的程度。

摘要(英)

In Taiwan, the number of GERD patients is increasing every year. This disease has a great effect on the patients metally and physically and on the quality of general life. Even the consumption of diagnosis and medical resources is very heavy. 〔1、2、3〕We are going to probe into the causes of the related risk factors of erosive esophagitis .
In this paper, we use Chi-square test and two sample t test to discuss that erosive esophagitis has relation to age, sex, smoking, alcohol, EGFV, weight and BMI or not. We also use Logistic Regression Model and Cumulative Logistic Regression Model to discuss risk factors of odds ratio of erosive esophagitis respectively. With the analysis, we are sure that the opportunity that age will significantly affect the increasing of incidence of the erosive esophagitis is not big enough at 0.05 significance level. The smoking and EGFV are most significant variable to get erosive esophagitis. After refusing the effect of age, sex,EGFV, and BMI, the men with smoke have significantly higher probability to get erosive esophagitis than the men without smoke.（Odds Ratio=5.342, 95% CI=2.908~9.813，p-value<0.0001. After refusing the effect of age, sex, smoke and BMI, the men with EGFV have significantly higher probability to get erosive esophagitis than the men without EGFV.（Odds Ratio=11.223, 95% CI=3.200~39.364，p-value=0.0002）. And using Cumulative Logistic Regression Model, we can also find smoking and EGFV are most significant variable to get erosive esophagitis. Besides, according our research, we realize that the longer observing time, the exacter erosive esophagitis diagnosis.

關鍵字(中)

★ 胃食道逆流疾病
★ 胃食道皮瓣
★ 糜爛性食道炎

關鍵字(英)

★ gastroesophageal flap valve
★ erosive esophagitis
★ gastroesophageal reflux disease

論文目次

摘要·······························································I
Abstract···························································II
致謝辭··························································· III
目錄·······························································IV
圖目錄···························································· VI
表目錄····························································VII
第一章緒論························································1
1-1研究背景····················································1
1-2研究方法····················································2
第二章研究方法····················································2
2-1 2×2列聯表卡方檢定···········································2
2-2 兩樣本的t檢定（Two sample t test）···························4
2-3 邏輯斯迴歸模型（Logistic Regression Model，LGRM）···········5
2-4 累積邏輯斯迴歸模型（Cumulative Logistic Regression Model，
CLGRM）······················································5
2-5 配對樣本t檢定··············································7
2-6 AIC（Akaike Information Criterion）·························8
第三章資料詳介····················································8
3-1資料型態····················································8
第四章資料分析···················································12
4-1自變數與食道炎之關係·······································12
4-2邏輯斯迴歸和累積邏輯斯迴歸分析·····························14
4-3檢定觀測時間···············································19
第五章結論·······················································24
參考文獻···························································26

參考文獻

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指導教授

鄒宗山(Tsung-Shan Tsou)

審核日期

2011-1-21

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