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姓名	劉家珮(Chia-pei Liu)  查詢紙本館藏	畢業系所	材料科學與工程研究所
論文名稱	表面改質對二氧化鈦奈米管的生物相容性與抗菌性影響之研究 (The Influence of Surface Modification on Biocompatibility and Antibacterial Activity of Titanium Oxide Nanotubes)
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摘要(中)	在組織植入技術領域中，隨著奈米尺度的生物材料逐漸受到重視，材料表面之組織相容性及細胞的生存與否，都深受材料表面形貌、粗糙度，及表面化學修飾的影響。本論文第一部分主要探討超臨界流體(ScCO2)清潔與紫外線光照(UV-irradiation)處理對於陽極氧化二氧化鈦(TiO2)奈米管表面性質的影響, 以及人體纖維組織母細胞(Human fibroblast cell) 在不同管徑之TiO2奈米管上之生物相容性。實驗結果顯示，經ScCO2清潔後，因材料表面之C-H鍵結的產生，TiO2奈米管的接觸角大幅上升。接著，將試片施以UV光照8小時，可藉由C-H鍵的分解而明顯改善材料表面之親水性; 且隨著管徑的下降，親水性的效果越好。此光誘發之親水性TiO2奈米管對於人體纖維母細胞具有良好的的生物相容性，且人體纖維母細胞的吸附及成長皆與奈米管徑大小具有高的相依性。在本論文的第二部分將探討銀奈米粒子在不同管徑之TiO2奈米管上的抗菌效果。實驗結果顯示, 在TiO2奈米管上的銀奈米粒子藉由銀離子的釋放可以成功地抑制葡萄球菌生長, 並改變其生長形貌, 進而大幅減少菌落的產生。此外, 細胞培養實驗顯示, 鍍有銀奈米粒子的TiO2奈米管除了有顯著的抗菌活性外, 同時也具有良好的生物相容性。總結以上所述, 利用超臨界流體清潔與銀奈米粒子的沉積可以有效地對植入性生醫材料進行表面修飾處理, 進而提供良好的生物相容性及抗菌環境。
摘要(英)	In the field of tissue implant technology, the surface morphology, roughness, and surface chemical modification of the bio-inert materials play important roles in the compatibility of tissues and the survival of cells. This study investigated the biocompatibility of human fibroblast cells on anodic TiO2 nanotubes after supercritical-CO2-fluid (ScCO2) cleaning processes and the antibacterial efficiency of the Ag-decorated TiO2 nanotubes with Staphylococcus aureus. Self-organized vertically-orientated TiO2 nanotubes with defined diameters between 15 and 100 nm were fabricated on Ti foils using anodic oxidation processes. We found that ScCO2-treated TiO2 nanotubes can effectively recover their surface wettability under UV-light irradiation as a result of photo-oxidation of C-H functional groups formed on the surface. Besides, experimental results showed that this photo-induced hydrophilic TiO2 nanotubes exhibit high biocompatibility of human fibroblast cells critically dependent on the tube diameter. Furthermore, the Ag-decorated TiO2 nanotubes fabricated in this study successfully inhibit the growth of bacteria by the release of silver ions, and simultaneously being suitable for the cell growth of fibroblast. This study demonstrates that the use of ScCO2 fluid and Ag-deposition can be the promising approaches for surface treatments or modifications of bio-implants.
關鍵字(中)	★ 陽極氧化 ★ TiO2奈米管 ★ 超臨界流體 ★ 生物相容性 ★ 抗菌活性	關鍵字(英)	★ Anodization ★ TiO2 nanotubes ★ Supercritical fluid ★ Biocompatibility ★ Antibacterial activity
論文目次	Related Publication І Abstract П Acknowledgement VIV Contents VI List of Figures IX List of Tables XIV Chapter 1 Introduction 1 1.1 Application of Titanium Dioxide Nanotubes 1 1.2 The Fabrication Methods of Titanium Nanotubes 2 1.2.1 Template-Assisted Method 3 1.2.2 Hydrothermal treatment 6 1.2.3 Anodization 8 1.3 Biomedical Applications of Titanium Nanotubes 11 1.4 The Influence of Surface Modification of Titanium Nanotubes on the Biocompatibility 14 Chapter 2 Experimental Methods 15 2.1 Preparation of TiO2 nanotubes 15 2.2 The cleaning process by using the supercritical carbon dioxide 16 2.3 Ultraviolet (UV) illumination treatments 17 2.4 Deposition of silver particles 17 2.5 Silver ion release test 18 2.6 Human fibroblast cell culture 19 2.7 Cell adhesion assay 19 2.8 Scanning electronic microscopy (SEM) 21 2.9 Cell proliferation assay 21 2.10 Protein adsorption 22 2.11 Antibacterial test 23 2.12 Antiadhesive test 24 2.13 Statistical analysis 25 Chapter 3 Diameter-sensitive Biocompatibility of Anodic TiO2 Nanotubes Treated with Supercritical CO2 Fluid 26 3.1 Motivation 26 3.2 Results and Discussions 28 3.2.1 Materials Characterizations 28 3.2.2 Cell adhesion assay 38 3.2.3 Cell proliferation assay 41 3.3 Conclusions 43 Chapter 4 Both Enhanced Biocompatibility and Antibacterial Activity in Ag-decorated TiO2 Nanotubes 44 4.1 Motivation 44 4.2 Results and Discussions 45 4.2.1 Materials Characterizations 45 4.2.2 Silver ion release 51 4.2.3 Antibacterial test 53 4.2.4 Cell adhesion assay 57 4.2.5 Cell proliferation assay 61 4.2.6 Cell proliferation assay 62 3.3 Conclusions 65 Chapter 5 Future Work 66 References 69
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指導教授	李勝偉(Sheng-wei Lee)	審核日期	2013-6-27
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