| dc.description.abstract | With the rapid developments of industrial society, heavy work load and irregular dietary can cause risky factors of cardiovascular diseases for people. According to the survey reported by department of health, Executive Yuan in Taiwan, most leading causes (~30.3%) of death during year 2008 ~2012 were related to cardiovascular disease. In addition, about half of the leading causes of death, such as heart disease, cerebrovascular disease, diabetes, hypertension, kidney disease, etc., in Taiwan, are all related to cardiovascular diseases. Besides, in accordance with the survey of World Health Organization (WHO) in 2008, ~31% of fatality rate in the world was related to cardiovascular diseases. Many patients consult doctors and have physical examinations only when conditions are serious, not to mention that people cannot detect their diseases by means of physical self-examinations, because of a severe shortage of medical supports in many districts. Therefore, how to achieve self-examinations at home and implement early detections of cardiovascular related diseases is an important issue. Current clinical monitoring systems measures electrocardiogram (ECG), respiration, blood oxygen, and blood pressure. Among the four vital signs, instruments for continuously monitoring of ECG and blood oxygen have been developed. Nevertheless, continuous recording system for long-term monitoring of respiration and blood pressure have not been developed yet. Accordingly, this study aims to develop convenient wearable devices for continuous monitoring of blood pressure and respiration. For blood pressure, we utilized the pulse wave velocity (PWV) measured from the time difference between ECG and PPG to estimate continuous blood pressure. Regarding respiration, the Holo-Hilbert Spectral Analysis (HHSA) was adopted to transform wrist PPG signals into Holo-Hilbert spectrum, so that the respiration rate can be found from the modulation frequency in Holo-Hilbert spectrum. The study results of this thesis propose a prototype form continuous monitoring of blood pressure and respiration, and the vital signs recorded from the proposed system might be able to derive new biomarker for early detection of cardiovascular diseases. | en_US |